{"id":305,"date":"2025-07-15T11:36:00","date_gmt":"2025-07-15T18:36:00","guid":{"rendered":"https:\/\/www.lechengmedical.com\/?p=305"},"modified":"2025-07-15T11:36:00","modified_gmt":"2025-07-15T18:36:00","slug":"pluripotent-stem-cells-what-makes-them-special","status":"publish","type":"post","link":"https:\/\/www.lechengmedical.com\/zh\/pluripotent-stem-cells-what-makes-them-special\/","title":{"rendered":"\u591a\u80fd\u5e72\u7ec6\u80de\u2014\u2014\u5b83\u4eec\u6709\u4f55\u7279\u522b\u4e4b\u5904\uff1f"},"content":{"rendered":"<?xml encoding=\"UTF-8\"><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u80da\u80ce\u5f62\u6210\u65e9\u671f\u5c31\u5df2\u51fa\u73b0\uff0c\u6b64\u65f6\u5b83\u4eec\u5c1a\u672a\u5b8c\u5168\u5206\u5316\u3002\u8fd9\u4f7f\u5f97\u5b83\u4eec\u80fd\u591f\u751f\u6210\u5404\u79cd\u7c7b\u578b\u7684\u4eba\u4f53\u7ec6\u80de\uff0c\u4f8b\u5982\u795e\u7ecf\u5143\u3001\u8840\u7ec6\u80de\u548c\u808c\u8089\u7ec6\u80de\u3002\u79d1\u5b66\u5bb6\u8ba4\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u65e0\u9650\u590d\u5236\u81ea\u8eab\uff0c\u8fd9\u4e3a\u79d1\u7814\u548c\u533b\u5b66\u63d0\u4f9b\u4e86\u8bf8\u591a\u673a\u9047\u3002\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u662f\u4e00\u9879\u91cd\u5927\u53d1\u73b0\uff0c\u5b83\u4eec\u6709\u52a9\u4e8e\u75be\u75c5\u5efa\u6a21\u3001\u836f\u7269\u6d4b\u8bd5\u548c\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u5145\u5206\u5c55\u73b0\u4e86\u5b83\u4eec\u5bf9\u4eba\u7c7b\u7684\u5de8\u5927\u4ef7\u503c\u3002.<\/p><h2 class=\"wp-block-heading\">\u591a\u80fd\u5e72\u7ec6\u80de<\/h2><figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-orig-src=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/07\/image-11-2-1-1024x576.webp\" alt=\"\" class=\"lazyload wp-image-308\"><figcaption class=\"wp-element-caption\">\u56fe\u7247\u6765\u6e90\uff1a <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/pexels.com\">pexels<\/a><\/figcaption><\/figure><h3 class=\"wp-block-heading\">\u5b9a\u4e49<\/h3><p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/tag\/pluripotent-stem-cells\/\" rel=\"noreferrer noopener\">\u591a\u80fd\u5e72\u7ec6\u80de<\/a> \u8fd9\u4e9b\u7ec6\u80de\u5b58\u5728\u4e8e\u80da\u80ce\u65e9\u671f\uff0c\u6765\u6e90\u4e8e\u56ca\u80da\u7684\u5185\u7ec6\u80de\u56e2\uff0c\u56ca\u80da\u662f\u975e\u5e38\u5e7c\u5c0f\u7684\u80da\u80ce\u3002\u8fd9\u4e9b\u7ec6\u80de\u5c1a\u672a\u5206\u5316\u6210\u4efb\u4f55\u7279\u5b9a\u7c7b\u578b\uff0c\u51e0\u4e4e\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u4f8b\u5982\u795e\u7ecf\u7ec6\u80de\u3001\u808c\u8089\u7ec6\u80de\u6216\u809d\u7ec6\u80de\u3002\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u79f0\u5176\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u3002 <a href=\"https:\/\/www.lechengmedical.com\/zh\/what-are-embryonic-stem-cells-and-why-are-they-important\/\">\u5e72\u7ec6\u80de<\/a> \u53ef\u4ee5\u751f\u6210\u6210\u4eba\u4f53\u5185\u6240\u6709\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u5305\u62ec\u6765\u81ea\u4e09\u4e2a\u4e3b\u8981\u80da\u5c42\u7684\u7ec6\u80de\uff1a\u5916\u80da\u5c42\u3001\u4e2d\u80da\u5c42\u548c\u5185\u80da\u5c42\u3002\u8fd9\u4e9b\u80da\u5c42\u6709\u52a9\u4e8e\u5f62\u6210\u6240\u6709\u7ec4\u7ec7\u548c\u5668\u5b98\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u8fd8\u53ef\u4ee5\u751f\u6210\u751f\u6b96\u7ec6\u80de\uff0c\u800c\u751f\u6b96\u7ec6\u80de\u662f\u7e41\u6b96\u6240\u5fc5\u9700\u7684\u3002\u79d1\u5b66\u5bb6\u79f0\u5b83\u4eec\u4e3a\u201c\u771f\u6b63\u7684\u5e72\u7ec6\u80de\u201d\uff0c\u56e0\u4e3a\u5b83\u4eec\u529f\u80fd\u5f3a\u5927\uff0c\u7528\u9014\u5e7f\u6cdb\u3002.<\/p><h3 class=\"wp-block-heading\">\u72ec\u7279\u529f\u80fd<\/h3><p class=\"wp-block-paragraph\">\u591a\u80fd\u6027 <a href=\"https:\/\/www.lechengmedical.com\/zh\/yanai-my-ips-japans-bold-gambit-to-democratize-stem-cell-therapy\/\">\u5e72\u7ec6\u80de<\/a>\u7ec6\u80de\u5177\u6709\u4e00\u4e9b\u7279\u6b8a\u7684\u7279\u6027\uff0c\u4f7f\u5176\u4e0e\u5176\u4ed6\u7ec6\u80de\u6709\u6240\u4e0d\u540c\u3002\u9996\u5148\uff0c\u5b83\u4eec\u80fd\u591f\u81ea\u6211\u66f4\u65b0\u3002\u8fd9\u610f\u5473\u7740\u5b83\u4eec\u53ef\u4ee5\u957f\u65f6\u95f4\u590d\u5236\u81ea\u8eab\u800c\u4e0d\u53d1\u751f\u6539\u53d8\u3002\u5176\u6b21\uff0c\u5b83\u4eec\u53ef\u4ee5 <a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/stem-cell-differentiation-the-science-behind-cellular-reprogramming-in-medicine\/\" rel=\"noreferrer noopener\">\u8fdb\u884c\u5fae\u5206<\/a>. \u8fd9\u4f7f\u5f97\u5b83\u4eec\u80fd\u591f\u5206\u5316\u6210\u80da\u5c42\u3001\u80da\u5c42\u548c\u80da\u5c42\u4e2d\u7684\u4efb\u4f55\u4e00\u79cd\u7ec6\u80de\u3002\u8fd9\u4e9b\u80fd\u529b\u4f7f\u5b83\u4eec\u5728\u79d1\u7814\u548c\u533b\u5b66\u9886\u57df\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u4ef7\u503c\u3002.<\/p><p class=\"wp-block-paragraph\">\u5b83\u4eec\u7684\u7279\u6b8a\u6027\u8d28\u6e90\u4e8e\u7ec6\u80de\u5185\u67d0\u4e9b\u7279\u5b9a\u7684\u5206\u5b50\uff0c\u4f8b\u5982\u8f6c\u5f55\u56e0\u5b50Oct4\u3001Sox2\u548cNanog\u3002\u8fd9\u4e9b\u5206\u5b50\u5e2e\u52a9\u7ec6\u80de\u4fdd\u6301\u5e72\u7ec6\u80de\u72b6\u6001\uff0c\u5e76\u63a7\u5236\u5b83\u4eec\u4f55\u65f6\u5206\u5316\u6210\u5176\u4ed6\u7c7b\u578b\u3002\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5404\u79cd\u6d4b\u8bd5\u6765\u5224\u65ad\u7ec6\u80de\u662f\u5426\u771f\u6b63\u5177\u6709\u591a\u80fd\u6027\u3002\u4ed6\u4eec\u4f1a\u5bfb\u627e\u7ec6\u80de\u8868\u9762\u7684\u7279\u6b8a\u6807\u8bb0\u7269\uff0c\u5e76\u6d4b\u8bd5\u7ec6\u80de\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u662f\u5426\u80fd\u591f\u5206\u5316\u6210\u6240\u6709\u4e09\u4e2a\u80da\u5c42\u3002\u6709\u65f6\uff0c\u4ed6\u4eec\u8fd8\u4f1a\u5c06\u7ec6\u80de\u79fb\u690d\u5230\u5c0f\u9f20\u4f53\u5185\uff0c\u89c2\u5bdf\u5176\u662f\u5426\u80fd\u591f\u5f62\u6210\u7578\u80ce\u7624\u2014\u2014\u4e00\u79cd\u5305\u542b\u591a\u79cd\u7ec4\u7ec7\u7c7b\u578b\u7684\u80bf\u7624\u3002\u8fd9\u4e9b\u6d4b\u8bd5\u6709\u52a9\u4e8e\u8bc1\u5b9e\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u7279\u6b8a\u6027\u8d28\u3002.<\/p><h2 class=\"wp-block-heading\">\u4e3b\u8981\u7279\u5f81<\/h2><h3 class=\"wp-block-heading\">\u81ea\u6211\u66f4\u65b0<\/h3><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u80fd\u591f\u81ea\u6211\u590d\u5236\u3002\u5b83\u4eec\u53ef\u4ee5\u591a\u6b21\u5206\u88c2\uff0c\u4f46\u81ea\u8eab\u4fdd\u6301\u4e0d\u53d8\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u5206\u88c2\u540e\u4ecd\u80fd\u4fdd\u7559\u5176\u7279\u6b8a\u6027\u72b6\u3002\u8bb8\u591a\u56e0\u7d20\u5e2e\u52a9\u5b83\u4eec\u7ef4\u6301\u8fd9\u79cd\u80fd\u529b\u3002\u6765\u81ea\u7ec6\u80de\u5916\u7684\u4fe1\u53f7\u3001\u8f6c\u5f55\u56e0\u5b50\u548c\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u56e0\u5b50\u90fd\u81f3\u5173\u91cd\u8981\u3002\u5faeRNA\u548c\u4fdd\u62a4\u67d3\u8272\u4f53\u7684\u57fa\u56e0\u4e5f\u53d1\u6325\u7740\u4f5c\u7528\u3002DNA\u7532\u57fa\u5316\u63a7\u5236\u7740\u54ea\u4e9b\u57fa\u56e0\u88ab\u6fc0\u6d3b\u6216\u5173\u95ed\u3002\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u751f\u957f\u9700\u8981\u9002\u5f53\u7684\u4fe1\u53f7\u5e73\u8861\u3002Myc\u662f\u4e00\u79cd\u5173\u952e\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u7ec4\u86cb\u767dH3.3\u662f\u4e00\u79cd\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u56e0\u5b50\u3002\u4e24\u8005\u90fd\u6709\u52a9\u4e8e\u63a7\u5236\u57fa\u56e0\u6d3b\u6027\u3002Myc\u6709\u52a9\u4e8e\u7ef4\u6301\u5e72\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u5e76\u6709\u52a9\u4e8e\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u751f\u6210\u3002\u4f46\u5982\u679cMyc\u5931\u63a7\uff0c\u5219\u53ef\u80fd\u5bfc\u81f4\u80bf\u7624\u7684\u53d1\u751f\u3002\u79d1\u5b66\u5bb6\u4eec\u6b63\u5728\u4e0d\u65ad\u7814\u7a76\u8fd9\u4e9b\u673a\u5236\uff0c\u4ee5\u671f\u5f00\u53d1\u51fa\u66f4\u591a\u6709\u6548\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u3002 <a href=\"https:\/\/www.lechengmedical.com\/zh\/what-are-the-costs-of-different-stem-cell-treatments-in-2025\/\">\u5e72\u7ec6\u80de\u6cbb\u7597<\/a> \u66f4\u5b89\u5168\u3002.<\/p><h3 class=\"wp-block-heading\">\u5206\u5316<\/h3><p class=\"wp-block-paragraph\">\u5206\u5316\u662f\u6307\u591a\u80fd\u5e72\u7ec6\u80de\u8f6c\u5316\u4e3a\u7279\u6b8a\u7ec6\u80de\u7684\u8fc7\u7a0b\u3002\u5b83\u4eec\u53ef\u4ee5\u5206\u5316\u6210\u4e09\u4e2a\u80da\u5c42\u4e2d\u7684\u4efb\u4f55\u4e00\u79cd\u7ec6\u80de\u3002\u8fd9\u4f7f\u5f97\u5b83\u4eec\u5728\u79d1\u5b66\u548c\u533b\u5b66\u9886\u57df\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u5e94\u7528\u4ef7\u503c\u3002\u79d1\u5b66\u5bb6\u5df2\u7ecf\u8bc1\u5b9e\uff0c\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u6240\u6709\u4e09\u4e2a\u80da\u5c42\u3002\u4f8b\u5982\uff0c\u4e00\u4e9b\u7814\u7a76\u91c7\u7528\u4e86\u5168\u57fa\u56e0\u7ec4\u8868\u8fbe\u8c31\u548c\u67d3\u8272\u8d28\u514d\u75ab\u6c89\u6dc0\u6d4b\u5e8f\uff08ChIP-seq\uff09\u6280\u672f\u3002\u8fd9\u4e9b\u7814\u7a76\u63ed\u793a\u4e86NANOG\u3001OCT4\u548cSOX2\u7b49\u8f6c\u5f55\u56e0\u5b50\u5982\u4f55\u6307\u5bfc\u5206\u5316\u3002\u8fd9\u4e9b\u56e0\u5b50\u63a7\u5236\u7740EOMES\u7b49\u57fa\u56e0\u7684\u8868\u8fbe\u3002EOMES\u542f\u52a8\u5185\u80da\u5c42\u7ec6\u80de\u7684\u5206\u5316\u8fc7\u7a0b\u3002EOMES\u4e0eSMAD2\/3\u534f\u540c\u4f5c\u7528\uff0c\u6fc0\u6d3b\u5185\u80da\u5c42\u7ec6\u80de\u7684\u5206\u5316\u7f51\u7edc\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u80da\u5c42<\/th><th>\u5b9e\u9a8c\u65b9\u6cd5<\/th><th>\u4f7f\u7528\u7684\u6807\u8bb0<\/th><th>\u4e3b\u8981\u53d1\u73b0<\/th><\/tr><tr><td>\u5916\u80da\u5c42<\/td><td>\u5229\u7528hPSCs\u8fdb\u884c\u5fae\u56fe\u6848\u5316\u4ee5\u5f62\u6210\u653e\u5c04\u72b6\u56fe\u6848<\/td><td>PAX6\uff08\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5916\u80da\u5c42\uff09\uff0cAP-2\u03b1\uff08\u975e\u795e\u7ecf\u5916\u80da\u5c42\uff09<\/td><td>\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u81ea\u7ec4\u7ec7\u6210\u795e\u7ecf\u533a\u57df\u548c\u975e\u795e\u7ecf\u533a\u57df\u3002<\/td><\/tr><tr><td>\u4e2d\u80da\u5c42<\/td><td>\u5c06hPSCs\u5206\u5316\u4e3a\u4e2d\u80da\u5c42-\u5185\u80da\u5c42\uff0c\u5e76\u91cd\u65b0\u63a5\u79cd\u5230\u5916\u80da\u5c42\u5fae\u56fe\u6848\u4e0a<\/td><td>T\/Brachyury\uff08\u4e2d\u80da\u5c42\u6807\u5fd7\u7269\uff09<\/td><td>\u4e2d\u80da\u5c42\u7ec6\u80de\u4e0e\u795e\u7ecf\u5916\u80da\u5c42\u91cd\u53e0\uff0c\u5448\u73b0\u9009\u62e9\u6027\u5206\u5e03\u3002<\/td><\/tr><tr><td>\u5185\u80da\u5c42<\/td><td>\u5c06hPSCs\u5206\u5316\u4e3a\u4e2d\u80da\u5c42-\u5185\u80da\u5c42\uff0c\u5e76\u91cd\u65b0\u63a5\u79cd\u5230\u5916\u80da\u5c42\u5fae\u56fe\u6848\u4e0a<\/td><td>SOX17\uff08\u5185\u80da\u5c42\u6807\u8bb0\u7269\uff09<\/td><td>\u5185\u80da\u5c42\u7ec6\u80de\u805a\u96c6\u5728\u8fb9\u7f18\uff0c\u8bc1\u5b9e\u4e86\u5185\u80da\u5c42\u8c31\u7cfb\u3002<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\">\u5b9e\u9a8c\u5ba4\u91c7\u7528\u4e0d\u540c\u7684\u6b65\u9aa4\u6765\u5f15\u5bfc\u7ec6\u80de\u5206\u5316\u3002\u4ed6\u4eec\u9996\u5148\u4f7f\u7528\u4f18\u8d28\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u3002\u4ed6\u4eec\u4f1a\u5728\u57f9\u517b\u76bf\u4e0a\u5305\u88ab\u7ec6\u80de\uff0c\u5206\u6563\u7ec6\u80de\u96c6\u843d\uff0c\u5e76\u4f7f\u7528\u542b\u6709\u6291\u5236\u5242\u7684\u7279\u6b8a\u57f9\u517b\u57fa\u3002\u79d1\u5b66\u5bb6\u4eec\u4f1a\u5728\u7ec6\u80de\u5f00\u59cb\u5206\u5316\u524d\u540e\u89c2\u5bdf\u5b83\u4eec\u7684\u53d8\u5316\u3002\u5b9a\u5411\u5206\u5316\u5229\u7528\u7ec6\u80de\u56e0\u5b50\u3001\u57f9\u517b\u57fa\u548c\u57fa\u8d28\u6765\u8bf1\u5bfc\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u751f\u6210\u3002\u7eaf\u5316\u6b65\u9aa4\uff0c\u4f8b\u5982\u901a\u8fc7\u8868\u9762\u6807\u5fd7\u7269\u8fdb\u884c\u5206\u9009\uff0c\u6709\u52a9\u4e8e\u83b7\u5f97\u7eaf\u51c0\u7684\u7ec6\u80de\u3002\u6709\u4e9b\u6b65\u9aa4\u7b80\u5355\u6613\u884c\uff0c\u5e76\u4e14\u5bf9\u795e\u7ecf\u7ec6\u80de\u7684\u5206\u5316\u6548\u679c\u5f88\u597d\u3002\u800c\u53e6\u4e00\u4e9b\u6b65\u9aa4\uff0c\u4f8b\u5982\u2026\u2026 <a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/mscs-for-cardiovascular-disease-repairing-hearts-with-stem-cell-therapy\/\" rel=\"noreferrer noopener\">\u5fc3\u810f\u6216\u809d\u810f\u7ec6\u80de<\/a>, \u8fd9\u4e9b\u65b9\u6cd5\u96be\u5ea6\u66f4\u5927\uff0c\u9700\u8981\u66f4\u591a\u7814\u7a76\u3002\u4e13\u5bb6\u4eec\u6b63\u643a\u624b\u5408\u4f5c\uff0c\u4e0d\u65ad\u6539\u8fdb\u8fd9\u4e9b\u65b9\u6cd5\u3002\u4e86\u89e3\u5206\u5316\u673a\u5236\u5728\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\u4ecd\u7136\u81f3\u5173\u91cd\u8981\u3002.<\/p><h3 class=\"wp-block-heading\">\u8f6c\u5f55\u56e0\u5b50<\/h3><p class=\"wp-block-paragraph\">\u8f6c\u5f55\u56e0\u5b50\u662f\u80fd\u591f\u5f00\u542f\u6216\u5173\u95ed\u57fa\u56e0\u7684\u86cb\u767d\u8d28\u3002\u5728\u591a\u80fd\u5e72\u7ec6\u80de\u4e2d\uff0c\u4e00\u4e9b\u8f6c\u5f55\u56e0\u5b50\u5bf9\u4e8e\u7ef4\u6301\u5176\u7279\u6027\u81f3\u5173\u91cd\u8981\u3002Oct4\u3001Sox2\u3001c-Myc \u548c Klf4 \u53ef\u4ee5\u6539\u53d8\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u72b6\u6001\uff0c\u5b83\u4eec\u5c06\u6291\u5236\u6027\u7ec4\u86cb\u767d\u4fee\u9970\u66ff\u6362\u4e3a\u6d3b\u6027\u7ec4\u86cb\u767d\u4fee\u9970\uff0c\u4ece\u800c\u4f7f\u7ec6\u80de\u83b7\u5f97\u591a\u80fd\u6027\u3002\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\u548c\u7532\u57fa\u8f6c\u79fb\u9176\u7b49\u9176\u7c7b\u6709\u52a9\u4e8e\u5b8c\u6210\u8fd9\u4e9b\u6539\u53d8\u3002RNA\u5e72\u6270\u7b5b\u9009\u53d1\u73b0 Esrrb \u548c Tbx3 \u662f\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u6240\u5fc5\u9700\u7684\u3002\u5982\u679c\u8fd9\u4e9b\u57fa\u56e0\u88ab\u963b\u65ad\uff0c\u7ec6\u80de\u5c31\u4f1a\u5f00\u59cb\u53d1\u751f\u5206\u5316\u3002Nanog \u53ef\u4ee5\u963b\u6b62\u8fd9\u79cd\u5206\u5316\uff0c\u4f7f\u7ec6\u80de\u4fdd\u6301\u672a\u5206\u5316\u72b6\u6001\u3002\u5176\u4ed6\u91cd\u8981\u7684\u8f6c\u5f55\u56e0\u5b50\u5305\u62ec Nac1 \u548c Zfp281\uff0c\u5b83\u4eec\u4e0e Nanog \u534f\u540c\u4f5c\u7528\uff0c\u4fc3\u8fdb\u7ec6\u80de\u7684\u81ea\u6211\u66f4\u65b0\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u8f6c\u5f55\u56e0\u5b50<\/th><th>\u5728\u7ef4\u6301\u591a\u80fd\u6027\u4e2d\u7684\u4f5c\u7528<\/th><th>\u8bc1\u636e\u7c7b\u578b<\/th><\/tr><tr><td>10\u67084\u65e5<\/td><td>\u65e9\u671f\u53d1\u80b2\u548c\u591a\u80fd\u6027\u6240\u5fc5\u9700\uff1b\u5242\u91cf\u5f71\u54cd\u8c31\u7cfb\u9009\u62e9<\/td><td>\u9057\u4f20\u5b66\u7814\u7a76<\/td><\/tr><tr><td>Sox2<\/td><td>\u4e0e Oct4 \u534f\u540c\u8c03\u8282\u57fa\u56e0\uff1b\u5bf9\u591a\u80fd\u6027\u81f3\u5173\u91cd\u8981<\/td><td>\u86cb\u767d\u8d28-DNA\u7ed3\u5408\u529f\u80fd\u5206\u6790<\/td><\/tr><tr><td>\u7eb3\u8bfa\u683c<\/td><td>\u4fc3\u8fdb\u81ea\u6211\u66f4\u65b0\uff1b\u51cf\u5c11\u5bf9LIF\u7684\u9700\u6c42<\/td><td>\u529f\u80fd\u5206\u6790<\/td><\/tr><tr><td>Sall4\u3001Dax1\u3001Rif1<\/td><td>\u901a\u8fc7\u86cb\u767d\u8d28\u7f51\u7edc\u652f\u6301\u591a\u80fd\u6027<\/td><td>\u86cb\u767d\u8d28\u590d\u5408\u7269\u7814\u7a76\uff0cRNA\u7b5b\u9009<\/td><\/tr><tr><td>Esrrb\uff0cTbx3<\/td><td>\u81ea\u6211\u66f4\u65b0\u6240\u5fc5\u9700\uff1b\u7eb3\u7c73\u683c\u53ef\u4ee5\u633d\u6551\u635f\u5931<\/td><td>RNA\u5e72\u6270<\/td><\/tr><tr><td>Nac1\uff0cZfp281<\/td><td>\u4e0e\u7eb3\u7c73\u673a\u5668\u4eba\u4e92\u52a8\uff1b\u5bf9\u81ea\u6211\u66f4\u65b0\u81f3\u5173\u91cd\u8981<\/td><td>\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5206\u6790<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u8f6c\u5f55\u56e0\u5b50\u534f\u540c\u4f5c\u7528\uff0c\u5f62\u6210\u4e00\u4e2a\u7f51\u7edc\u3002\u5b83\u4eec\u63a7\u5236\u54ea\u4e9b\u57fa\u56e0\u5904\u4e8e\u6d3b\u8dc3\u72b6\u6001\uff0c\u7ef4\u6301\u7ec6\u80de\u672a\u5206\u5316\u72b6\u6001\uff0c\u5e76\u5e2e\u52a9\u5c06\u666e\u901a\u7ec6\u80de\u8f6c\u5316\u4e3a\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u3002\u5b83\u4eec\u7684\u534f\u540c\u4f5c\u7528\u4f7f\u5e72\u7ec6\u80de\u7684\u7279\u6027\u4fdd\u6301\u7a33\u5b9a\u3002.<\/p><blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u7b14\u8bb0\uff1a<\/strong> \u79d1\u5b66\u5bb6\u91c7\u7528\u591a\u79cd\u65b9\u6cd5\u6765\u68c0\u6d4b\u7ec6\u80de\u662f\u5426\u5177\u6709\u591a\u80fd\u6027\u3002\u4ed6\u4eec\u4f1a\u5728\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u7ec6\u80de\u7684\u5f62\u72b6\u548c\u7ed3\u6784\u3002\u4ed6\u4eec\u5229\u7528\u514d\u75ab\u8868\u578b\u5206\u6790\u548c\u6d41\u5f0f\u7ec6\u80de\u672f\u6765\u5bfb\u627e\u8bf8\u5982NANOG\u3001OCT4\u3001SSEA3\/4\u548cTRA-1-60\/81\u7b49\u6807\u8bb0\u7269\u3002\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f8b\u5982qRT-PCR\uff0c\u53ef\u4ee5\u68c0\u6d4b\u91cd\u8981\u7684\u57fa\u56e0\u3002\u57fa\u56e0\u68c0\u6d4b\u8fd8\u53ef\u4ee5\u5bfb\u627e\u7a33\u5b9a\u7684\u67d3\u8272\u4f53\u3002\u529f\u80fd\u6027\u68c0\u6d4b\uff0c\u4f8b\u5982\u80da\u72b6\u4f53\u5f62\u6210\u548c\u5b9a\u5411\u5206\u5316\uff0c\u53ef\u4ee5\u663e\u793a\u7ec6\u80de\u662f\u5426\u80fd\u591f\u5206\u5316\u6210\u4e0d\u540c\u7684\u7c7b\u578b\u3002\u6d41\u5f0f\u7ec6\u80de\u672f\u662f\u5bfb\u627e\u591a\u80fd\u6027\u6807\u8bb0\u7269\u7684\u6709\u6548\u65b9\u6cd5\u3002\u7efc\u5408\u8fd0\u7528\u6240\u6709\u8fd9\u4e9b\u68c0\u6d4b\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5168\u9762\u4e86\u89e3\u5e72\u7ec6\u80de\u7684\u8d28\u91cf\u548c\u5b89\u5168\u6027\u3002.<\/p>\n<\/blockquote><h2 class=\"wp-block-heading\">\u4e0e\u5176\u4ed6\u5e72\u7ec6\u80de\u7684\u6bd4\u8f83<\/h2><h3 class=\"wp-block-heading\">\u5168\u80fd\u8005<\/h3><p class=\"wp-block-paragraph\">\u5168\u80fd\u5e72\u7ec6\u80de\u4f4d\u4e8e\u5e72\u7ec6\u80de\u5bb6\u65cf\u7684\u9876\u7aef\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u5375\u5b50\u548c\u7cbe\u5b50\u7ed3\u5408\u540e\u7acb\u5373\u51fa\u73b0\uff0c\u5b58\u5728\u4e8e\u53d7\u7cbe\u5375\u548c\u65e9\u671f\u5375\u88c2\u7403\u4e2d\u3002\u5168\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u6240\u6709\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u8fd8\u80fd\u5f62\u6210\u80ce\u76d8\u548c\u5375\u9ec4\u56ca\u7b49\u989d\u5916\u7ec4\u7ec7\uff0c\u8fd9\u4f7f\u5b83\u4eec\u4e0e\u5176\u4ed6\u5e72\u7ec6\u80de\u6709\u6240\u4e0d\u540c\u3002\u5168\u80fd\u5e72\u7ec6\u80de\u548c\u591a\u80fd\u5e72\u7ec6\u80de\u90fd\u5229\u7528\u91cd\u8981\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u4f8b\u5982Oct4\u3001Sox2\u548cNanog\u3002\u4f46\u5168\u80fd\u5e72\u7ec6\u80de\u5177\u6709\u4e00\u4e9b\u7279\u6b8a\u7684\u6807\u8bb0\u7269\uff0c\u4f8b\u5982Zscan4\u548cEomes\u3002\u5b83\u4eec\u7684\u67d3\u8272\u8d28\u7ed3\u6784\u66f4\u52a0\u5f00\u653e\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u4eec\u7684DNA\u66f4\u5bb9\u6613\u88ab\u57fa\u56e0\u5229\u7528\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u7ec6\u80de\u7c7b\u578b<\/th><th>\u53d1\u5c55\u6f5c\u529b<\/th><th>\u80da\u80ce\u671f<\/th><\/tr><tr><td>\u5168\u80fd\u8005<\/td><td>\u53ef\u4ee5\u5206\u5316\u5f62\u6210\u6240\u6709\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u80da\u5916\u7ec4\u7ec7\uff08\u4f8b\u5982\u80ce\u76d8\u3001\u5375\u9ec4\u56ca\uff09<\/td><td>\u53d7\u7cbe\u5375\u548c\u65e9\u671f\u5375\u88c2\u7403<\/td><\/tr><tr><td>\u591a\u80fd\u6027<\/td><td>\u53ef\u4ee5\u5206\u5316\u6210\u4e09\u4e2a\u80da\u5c42\uff08\u5185\u80da\u5c42\u3001\u4e2d\u80da\u5c42\u3001\u5916\u80da\u5c42\uff09\u7684\u6240\u6709\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u4e0d\u80fd\u5f62\u6210\u80da\u5916\u7ec4\u7ec7\u3002<\/td><td>\u56ca\u80da\u5185\u7ec6\u80de\u56e2<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\">\u5f53\u5168\u80fd\u7ec6\u80de\u8f6c\u53d8\u4e3a\u591a\u80fd\u7ec6\u80de\u65f6\uff0c\u5b83\u4eec\u7684\u57fa\u56e0\u4e5f\u4f1a\u53d1\u751f\u53d8\u5316\u3002\u5728\u8fd9\u4e2a\u8f6c\u53d8\u8fc7\u7a0b\u4e2d\uff0c\u4e00\u4e9b\u57fa\u56e0\u4f1a\u5173\u95ed\uff0c\u800c\u53e6\u4e00\u4e9b\u57fa\u56e0\u5219\u4f1a\u5f00\u542f\u3002.<\/p><h3 class=\"wp-block-heading\">\u591a\u80fd<\/h3><p class=\"wp-block-paragraph\">\u591a\u80fd <a href=\"https:\/\/www.lechengmedical.com\/zh\/boost-recovery-discover-what-stem-cells-can-do-now\/\">\u5e72\u7ec6\u80de\u53ef\u4ee5<\/a> \u591a\u80fd\u5e72\u7ec6\u80de\u53ea\u80fd\u5206\u5316\u6210\u5c11\u6570\u51e0\u79cd\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u5b83\u4eec\u7684\u5206\u5316\u9009\u62e9\u4e0d\u5982\u591a\u80fd\u5e72\u7ec6\u80de\u6216\u5168\u80fd\u5e72\u7ec6\u80de\u90a3\u4e48\u591a\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u5b58\u5728\u4e8e\u6210\u4eba\u4f53\u5185\uff0c\u9020\u8840\u5e72\u7ec6\u80de\u548c\u795e\u7ecf\u5e72\u7ec6\u80de\u662f\u4e24\u4e2a\u4e3b\u8981\u7684\u4f8b\u5b50\u3002\u9020\u8840\u5e72\u7ec6\u80de\u4ea7\u751f\u6240\u6709\u8840\u7ec6\u80de\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u4ea7\u751f\u5927\u8111\u548c\u795e\u7ecf\u4e2d\u7684\u4e3b\u8981\u7ec6\u80de\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u6709\u52a9\u4e8e\u4fee\u590d\u548c\u7ef4\u6301\u7ec4\u7ec7\u5065\u5eb7\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u65b9\u9762<\/th><th>\u591a\u80fd\u5e72\u7ec6\u80de<\/th><th>\u591a\u80fd\u5e72\u7ec6\u80de<\/th><\/tr><tr><td>\u5dee\u5f02\u5316\u80fd\u529b<\/td><td>\u80fd <a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/tag\/stem-cell-differentiation\/\" rel=\"noreferrer noopener\">\u5206\u5316\u6210\u6240\u6709\u7ec6\u80de\u7c7b\u578b<\/a> \u7531\u4e09\u4e2a\u80da\u5c42\uff08\u5916\u80da\u5c42\u3001\u4e2d\u80da\u5c42\u3001\u5185\u80da\u5c42\uff09\u884d\u751f\u800c\u6765\u3002.<\/td><td>\u53ea\u80fd\u5206\u5316\u6210\u7279\u5b9a\u7ec4\u7ec7\u6216\u5668\u5b98\u8c31\u7cfb\u4e2d\u6709\u9650\u6570\u91cf\u7684\u7ec6\u80de\u7c7b\u578b\u3002.<\/td><\/tr><tr><td>\u793a\u4f8b<\/td><td><a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/what-are-embryonic-stem-cells-and-why-are-they-important\/\" rel=\"noreferrer noopener\">\u80da\u80ce\u5e72\u7ec6\u80de<\/a> \uff08\u80da\u80ce\u5e72\u7ec6\u80de\uff09\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09<\/td><td>\u9020\u8840\u5e72\u7ec6\u80de\uff08HSCs\uff09, <a href=\"https:\/\/www.lechengmedical.com\/zh\/unleashing-the-potential-of-mesenchymal-stem-cells-in-rheumatic-disease-treatment\/\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/a> \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u3001\u795e\u7ecf\u5e72\u7ec6\u80de<\/td><\/tr><tr><td>\u6765\u6e90<\/td><td>\u65e9\u671f\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09\u3001\u91cd\u7f16\u7a0b\u7684\u6210\u4f53\u7ec6\u80de\uff08iPSCs\uff09<\/td><td>\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u3001, <a href=\"https:\/\/www.lechengmedical.com\/zh\/treating-covid-19-with-human-umbilical-cord-mesenchymal-stem-cells-uc-mscs-a-promising-approach\/\">\u8110\u5e26<\/a> \u8840<\/td><\/tr><tr><td>\u4e34\u5e8a\u5e94\u7528<\/td><td>\u7531\u4e8e\u80fd\u591f\u751f\u6210\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u56e0\u6b64\u5728\u518d\u751f\u533b\u5b66\u9886\u57df\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/td><td>\u7528\u4e8e\u9488\u5bf9\u7279\u5b9a\u7ec4\u7ec7\uff08\u4f8b\u5982\u8840\u6db2\u3001\u9aa8\u9abc\uff09\u7684\u9776\u5411\u4fee\u590d\u6cbb\u7597<\/td><\/tr><tr><td>\u6548\u529b\u63cf\u8ff0<\/td><td>\u4f53\u5185\u7ec6\u80de\u7c7b\u578b\u5177\u6709\u65e0\u9650\u7684\u5206\u5316\u6f5c\u80fd<\/td><td>\u5206\u5316\u6f5c\u80fd\u6709\u9650\uff0c\u4ec5\u9650\u4e8e\u76f8\u5173\u7ec6\u80de\u8c31\u7cfb<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u5728\u6210\u4eba\u4f53\u5185\u6700\u4e3a\u5e38\u89c1\u3002\u79d1\u5b66\u5bb6\u5229\u7528\u9020\u8840\u5e72\u7ec6\u80de\u6cbb\u7597\u8840\u6db2\u75be\u75c5\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u6709\u52a9\u4e8e\u4fee\u590d\u795e\u7ecf\u7cfb\u7edf\u3002\u8fd9\u4e9b\u6210\u4f53\u5e72\u7ec6\u80de\u5728\u6211\u4eec\u8870\u8001\u7684\u8fc7\u7a0b\u4e2d\u7ef4\u6301\u7740\u7ec4\u7ec7\u7684\u6b63\u5e38\u529f\u80fd\u3002.<\/p><h3 class=\"wp-block-heading\">\u5355\u80fd<\/h3><p class=\"wp-block-paragraph\">\u5355\u80fd\u5e72\u7ec6\u80de\u53ea\u80fd\u5206\u5316\u6210\u4e00\u79cd\u7ec6\u80de\u3002\u4f8b\u5982\uff0c\u5b83\u4eec\u53ef\u80fd\u53ea\u80fd\u5206\u5316\u6210\u76ae\u80a4\u7ec6\u80de\u6216\u808c\u8089\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u5b58\u5728\u4e8e\u6210\u4eba\u7ec4\u7ec7\u4e2d\uff0c\u5e2e\u52a9\u66ff\u6362\u8870\u8001\u6216\u53d7\u635f\u7684\u7ec6\u80de\u3002\u5355\u80fd\u5e72\u7ec6\u80de\u4e0d\u80fd\u5206\u5316\u6210\u5176\u4ed6\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u4f46\u5b83\u4eec\u5bf9\u4e8e\u7ef4\u6301\u7ec4\u7ec7\u5065\u5eb7\u4ecd\u7136\u81f3\u5173\u91cd\u8981\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\u3002\u5355\u80fd\u5e72\u7ec6\u80de\u5c55\u793a\u4e86\u4eba\u4f53\u5982\u4f55\u5229\u7528\u4e0d\u540c\u7684\u5e72\u7ec6\u80de\u6267\u884c\u4e0d\u540c\u7684\u529f\u80fd\u3002\u968f\u7740\u7ec6\u80de\u4ece\u5168\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u518d\u5206\u5316\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u548c\u5355\u80fd\u5e72\u7ec6\u80de\uff0c\u5b83\u4eec\u4f1a\u9010\u6e10\u5931\u53bb\u4e00\u4e9b\u5206\u5316\u80fd\u529b\u3002\u6210\u4f53\u5e72\u7ec6\u80de\uff0c\u5305\u62ec\u591a\u80fd\u5e72\u7ec6\u80de\u548c\u5355\u80fd\u5e72\u7ec6\u80de\uff0c\u5728\u9700\u8981\u65f6\u901a\u8fc7\u4ea7\u751f\u65b0\u7684\u7ec6\u80de\u6765\u5e2e\u52a9\u7ec4\u7ec7\u7ef4\u6301\u5065\u5eb7\u3002.<\/p><blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u6ce8\uff1a\u79d1\u5b66\u5bb6\u7814\u7a76\u6240\u6709\u8fd9\u4e9b\u5e72\u7ec6\u80de\u7c7b\u578b\uff0c\u4ee5\u4e86\u89e3\u4eba\u4f53\u5982\u4f55\u751f\u957f\u548c\u4fee\u590d\u3002\u6bcf\u79cd\u5e72\u7ec6\u80de\u5728\u4eba\u4f53\u548c\u533b\u5b66\u4e2d\u90fd\u53d1\u6325\u7740\u7279\u6b8a\u4f5c\u7528\u3002\u4e86\u89e3\u5b83\u4eec\u4e4b\u95f4\u7684\u5dee\u5f02\u6709\u52a9\u4e8e\u7814\u7a76\u4eba\u5458\u4e3a\u6bcf\u79cd\u6cbb\u7597\u9009\u62e9\u6700\u4f73\u7684\u5e72\u7ec6\u80de\u3002.<\/p>\n<\/blockquote><h2 class=\"wp-block-heading\">\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u7c7b\u578b<\/h2><figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-orig-src=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/07\/image-11-1-1-1024x576.webp\" alt=\"\" class=\"lazyload wp-image-307\"><figcaption class=\"wp-element-caption\">\u56fe\u7247\u6765\u6e90\uff1a <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/pexels.com\">pexels<\/a><\/figcaption><\/figure><h3 class=\"wp-block-heading\">\u80da\u80ce\u5e72\u7ec6\u80de<\/h3><p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/what-are-embryonic-stem-cells-and-why-are-they-important\/\" rel=\"noreferrer noopener\">\u80da\u80ce\u5e72\u7ec6\u80de<\/a> \u8fd9\u4e9b\u7ec6\u80de\u6765\u6e90\u4e8e\u56ca\u80da\u5185\u90e8\u3002\u79d1\u5b66\u5bb6\u4e8e1981\u5e74\u9996\u6b21\u5728\u5c0f\u9f20\u80da\u80ce\u4e2d\u53d1\u73b0\u4e86\u8fd9\u4e9b\u7ec6\u80de\u30021998\u5e74\uff0c\u4ed6\u4eec\u5efa\u7acb\u4e86\u9996\u6279\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u7cfb\u3002\u8fd9\u4e9b\u7ec6\u80de\u51e0\u4e4e\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u662f\u591a\u80fd\u6027\u7684\u6700\u4f73\u4f8b\u8bc1\u3002.<\/p><p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\u83b7\u53d6\u80da\u80ce\u5e72\u7ec6\u80de\uff1a<\/p><ul class=\"wp-block-list\">\n<li>\u673a\u68b0\u89e3\u5256\u6cd5\u4f7f\u7528\u5de5\u5177\u5c06\u5185\u7ec6\u80de\u56e2\u53d6\u51fa\u3002\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u4f7f\u7528\u52a8\u7269\u5236\u54c1\uff0c\u4f46\u8017\u65f6\u66f4\u957f\u3002.<\/li>\n\n\n\n<li>\u6fc0\u5149\u89e3\u5256\u672f\u5229\u7528\u6fc0\u5149\u5207\u9664\u5185\u7ec6\u80de\u56e2\u3002\u8fd9\u79cd\u65b9\u6cd5\u975e\u5e38\u7cbe\u786e\uff0c\u4f46\u8d39\u7528\u5f88\u9ad8\u3002.<\/li>\n\n\n\n<li>\u514d\u75ab\u5916\u79d1\u624b\u672f\u5229\u7528\u6297\u4f53\u548c\u52a8\u7269\u8840\u6e05\u6765\u6e05\u9664\u591a\u4f59\u7ec6\u80de\u3002\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u8bca\u6240\u6765\u8bf4\u5e76\u4e0d\u7406\u60f3\uff0c\u56e0\u4e3a\u5b83\u4f7f\u7528\u4e86\u52a8\u7269\u5236\u54c1\u3002.<\/li>\n<\/ul><p class=\"wp-block-paragraph\">\u83b7\u53d6\u7ec6\u80de\u540e\uff0c\u79d1\u5b66\u5bb6\u5c06\u5176\u57f9\u517b\u5728\u9972\u517b\u5c42\u6216\u7279\u6b8a\u8868\u9762\u4e0a\uff0c\u4ee5\u9632\u6b62\u7ec6\u80de\u53d1\u751f\u53d8\u5f02\u3002\u4f7f\u7528\u8fd9\u4e9b\u7ec6\u80de\u6709\u4e25\u683c\u7684\u89c4\u5b9a\u3002\u6350\u8d60\u8005\u5fc5\u987b\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u5e76\u4e14\u7814\u7a76\u5fc5\u987b\u7ecf\u8fc7\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u5ba1\u67e5\u3002\u6cd5\u5f8b\u7981\u6b62\u51fa\u552e\u4eba\u7c7b\u5375\u5b50\u6216\u80da\u80ce\u7528\u4e8e\u7814\u7a76\u3002\u4e00\u4e9b\u5dde\u5141\u8bb8\u8fdb\u884c\u6b64\u7c7b\u7814\u7a76\uff0c\u800c\u53e6\u4e00\u4e9b\u5dde\u5219\u4e0d\u5141\u8bb8\u3002\u76f8\u5173\u59d4\u5458\u4f1a\u8d1f\u8d23\u786e\u4fdd\u6240\u6709\u89c4\u5b9a\u5f97\u5230\u9075\u5b88\u3002.<\/p><blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u4eba\u4eec\u5c31\u80da\u80ce\u5e72\u7ec6\u80de\u4e89\u8bba\u4e0d\u4f11\uff0c\u4e89\u8bba\u7684\u7126\u70b9\u5728\u4e8e\u80da\u80ce\u7684\u6027\u8d28\u4ee5\u53ca\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u7684\u5fc5\u8981\u6027\u3002\u6709\u4e9b\u4eba\u62c5\u5fc3\u4ec5\u4ec5\u4e3a\u4e86\u7814\u7a76\u800c\u5236\u9020\u80da\u80ce\uff0c\u800c\u53e6\u4e00\u4e9b\u4eba\u5219\u8ba4\u4e3a\u8fd9\u9879\u7814\u7a76\u5bf9\u533b\u5b66\u6709\u76ca\u3002.<\/p>\n<\/blockquote><h3 class=\"wp-block-heading\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de<\/h3><p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/stem-cell-differentiation-the-science-behind-cellular-reprogramming-in-medicine\/\" rel=\"noreferrer noopener\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de<\/a> \u591a\u80fd\u5e72\u7ec6\u80de\u662f\u901a\u8fc7\u6539\u9020\u6210\u4f53\u7ec6\u80de\u800c\u4ea7\u751f\u7684\u3002\u79d1\u5b66\u5bb6\u5229\u7528\u4e00\u4e9b\u7279\u6b8a\u7684\u86cb\u767d\u8d28\uff0c\u4f8b\u5982 Oct4\u3001Sox2\u3001c-Myc \u548c Klf4 \u6765\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u3002\u4ed6\u4eec\u91c7\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u75c5\u6bd2\u8f7d\u4f53\u3001\u86cb\u767d\u8d28\u9012\u9001\u6216\u5316\u5b66\u7269\u8d28\u3002\u4f8b\u5982\uff0c\u5728\u76ae\u80a4\u7ec6\u80de\u4e2d\u6dfb\u52a0 Lin28-30Kc19 \u86cb\u767d\uff0c\u53ef\u4ee5\u5728\u4e00\u5468\u5185\u4f7f\u591a\u80fd\u5e72\u7ec6\u80de\u514b\u9686\u7684\u6570\u91cf\u589e\u52a0 1.5 \u500d\u3002\u8fd9\u53ef\u4ee5\u63d0\u9ad8\u8f6c\u5316\u6548\u7387\u3002.<\/p><p class=\"wp-block-paragraph\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6709\u671b\u52a9\u529b\u4e2a\u6027\u5316\u533b\u7597\u3002\u533b\u751f\u53ef\u4ee5\u5229\u7528\u60a3\u8005\u81ea\u8eab\u7684\u7ec6\u80de\u6765\u6784\u5efa\u65b0\u7684\u7ec4\u7ec7\u3002\u4f46\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u7ec6\u80de\u53ef\u80fd\u5b58\u5728\u66f4\u591a\u9057\u4f20\u95ee\u9898\uff0c\u4e5f\u53ef\u80fd\u4fdd\u7559\u4e00\u4e9b\u6765\u81ea\u539f\u59cb\u6210\u4f53\u7ec6\u80de\u7684\u7279\u5f81\u3002\u79d1\u5b66\u5bb6\u4eec\u6b63\u81f4\u529b\u4e8e\u4f7f\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u66f4\u5b89\u5168\u3001\u66f4\u9002\u7528\u4e8e\u60a3\u8005\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u65b9\u9762<\/th><th>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09<\/th><th>\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09<\/th><\/tr><tr><td>\u9057\u4f20\u7a33\u5b9a\u6027<\/td><td>\u66f4\u4f4e\uff0c\u66f4\u591a\u7a81\u53d8<\/td><td>\u66f4\u9ad8\u3001\u66f4\u5c11\u7684\u7a81\u53d8<\/td><\/tr><tr><td>\u4e34\u5e8a\u6f5c\u529b<\/td><td>\u4e2a\u6027\u5316\u6cbb\u7597\uff0c\u5b89\u5168\u95ee\u9898<\/td><td>\u9ad8\u5c42\u6b21\u7684\u4f26\u7406\u8fa9\u8bba<\/td><\/tr><tr><td>\u8d77\u6e90<\/td><td>\u91cd\u7f16\u7a0b\u7684\u6210\u5e74\u7ec6\u80de<\/td><td>\u80da\u80ce\u5185\u7ec6\u80de\u56e2<\/td><\/tr><\/tbody><\/table><\/figure><h3 class=\"wp-block-heading\">\u80da\u80ce\u751f\u6b96\u7ec6\u80de<\/h3><p class=\"wp-block-paragraph\">\u80da\u80ce\u751f\u6b96\u7ec6\u80de\u6765\u6e90\u4e8e\u539f\u59cb\u751f\u6b96\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u51fa\u73b0\u8f83\u65e9\uff0c\u4e4b\u540e\u4f1a\u5206\u5316\u6210\u7cbe\u5b50\u6216\u5375\u5b50\u3002\u80da\u80ce\u751f\u6b96\u7ec6\u80de\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u6709\u5f88\u591a\u76f8\u4f3c\u4e4b\u5904\uff0c\u56e0\u4e3a\u5b83\u4eec\u90fd\u5177\u6709\u591a\u80fd\u6027\u3002\u4f46\u7531\u4e8e\u5176\u6765\u6e90\u7684\u7279\u6b8a\u6027\uff0c\u5b83\u4eec\u5177\u6709\u7279\u6b8a\u7684\u8868\u89c2\u9057\u4f20\u6a21\u5f0f\u3002\u751f\u6b96\u7ec6\u80de\u4f1a\u6e05\u9664\u8bb8\u591aDNA\u6807\u8bb0\uff0c\u4ece\u800c\u6539\u53d8\u5b83\u4eec\u6700\u7ec8\u80fd\u591f\u5206\u5316\u6210\u7684\u7ec6\u80de\u7c7b\u578b\u3002.<\/p><p class=\"wp-block-paragraph\">\u80da\u80ce\u751f\u6b96\u7ec6\u80de\u548c\u80da\u80ce\u5e72\u7ec6\u80de\u90fd\u80fd\u5206\u5316\u6210\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u79d1\u5b66\u5bb6\u7814\u7a76\u8fd9\u4e9b\u7ec6\u80de\uff0c\u4ee5\u4e86\u89e3\u4eba\u4f53\u7684\u751f\u957f\u53d1\u80b2\u8fc7\u7a0b\u4ee5\u53ca\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u3002\u751f\u6b96\u7ec6\u80de\u4e5f\u5341\u5206\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u5c06\u57fa\u56e0\u4f20\u9012\u7ed9\u4e0b\u4e00\u4ee3\u3002.<\/p><h2 class=\"wp-block-heading\">\u5e94\u7528\u7a0b\u5e8f<\/h2><h3 class=\"wp-block-heading\">\u7814\u7a76<\/h3><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u5728\u7814\u7a76\u4e2d\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u5b83\u4eec\u6765\u7814\u7a76\u75be\u75c5\u53ca\u5176\u53d1\u751f\u673a\u5236\u3002\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u53ef\u4ee5\u5206\u5316\u6210\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u7528\u4e8e\u8fd9\u4e9b\u7814\u7a76\u3002\u8fd9\u6709\u52a9\u4e8e\u6784\u5efa\u6a21\u62df\u771f\u5b9e\u75be\u75c5\u7684\u6a21\u578b\u3002\u8fd9\u4e9b\u6a21\u578b\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u6d4b\u8bd5\u65b0\u836f\u3002\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u7814\u7a76\u9057\u4f20\u6027\u75be\u75c5\uff0c\u4f8b\u5982\u5148\u5929\u6027\u5fc3\u810f\u75c5\u3002iPSCs\u4e0e\u60a3\u8005\u62e5\u6709\u76f8\u540c\u7684\u57fa\u56e0\u3002\u8fd9\u6709\u52a9\u4e8e\u79d1\u5b66\u5bb6\u4e86\u89e3\u75be\u75c5\u7684\u8fd0\u4f5c\u673a\u5236\u3002\u52a8\u7269\u6a21\u578b\u5e76\u4e0d\u603b\u662f\u80fd\u5b8c\u5168\u6a21\u62df\u4eba\u7c7b\u7684\u884c\u4e3a\u3002iPSCs\u6709\u52a9\u4e8e\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002\u5b83\u4eec\u53ef\u4ee5\u5927\u91cf\u589e\u6b96\uff0c\u56e0\u6b64\u6d4b\u8bd5\u66f4\u52a0\u4fbf\u6377\u3002\u5229\u75283D\u57f9\u517b\u548c\u7279\u6b8a\u86cb\u767d\u8d28\uff0c\u79d1\u5b66\u5bb6\u53ef\u4ee5\u4f7f\u7ec6\u80de\u50cf\u771f\u5b9e\u7ec4\u7ec7\u4e00\u6837\u8fd0\u4f5c\u3002\u8fd9\u4e9b\u5e94\u7528\u6709\u52a9\u4e8e\u4e2a\u6027\u5316\u533b\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u5728\u65b0\u7597\u6cd5\u65b9\u9762\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002.<\/p><ul class=\"wp-block-list\">\n<li>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6709\u52a9\u4e8e\u6a21\u62df\u5fc3\u5f8b\u5931\u5e38\u548c\u5176\u4ed6\u9057\u4f20\u6027\u75be\u75c5\u3002.<\/li>\n\n\n\n<li>\u4ed6\u4eec\u8ba9\u79d1\u5b66\u5bb6\u5728\u7c7b\u4f3c\u4eba\u4f53\u7ec6\u80de\u7684\u7ec6\u80de\u4e0a\u6d4b\u8bd5\u836f\u7269\u3002.<\/li>\n\n\n\n<li>iPSCs \u7528\u4e8e\u89c2\u5bdf\u7ec6\u80de\u5bf9\u4e0d\u540c\u6cbb\u7597\u7684\u53cd\u5e94\u3002.<\/li>\n<\/ul><h3 class=\"wp-block-heading\">\u836f\u54c1<\/h3><p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/tag\/clinical-applications\/\" rel=\"noreferrer noopener\">\u591a\u80fd\u5e72\u7ec6\u80de\u975e\u5e38\u91cd\u8981<\/a> \u5728\u518d\u751f\u533b\u5b66\u9886\u57df\uff0c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u4ece\u800c\u5e2e\u52a9\u4fee\u590d\u6216\u66ff\u6362\u53d7\u635f\u7ec4\u7ec7\u3002\u533b\u751f\u5229\u7528\u5b83\u4eec\u6765\u8f85\u52a9\u6cbb\u7597\u5fc3\u810f\u3001\u773c\u775b\u548c\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3002\u7531\u4e8eiPSCs\u6765\u6e90\u4e8e\u60a3\u8005\u81ea\u8eab\uff0c\u56e0\u6b64\u4e0d\u4f1a\u5f15\u8d77\u6392\u5f02\u53cd\u5e94\u3002\u8bf8\u5982\u975e\u75c5\u6bd2\u91cd\u7f16\u7a0b\u7b49\u65b0\u6280\u672f\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u66f4\u52a0\u5b89\u5168\u3002\u751f\u7269\u5de5\u7a0b\u5de5\u5177\u53ef\u4ee5\u5e2e\u52a9\u57f9\u80b2\u7528\u4e8e\u79fb\u690d\u7684\u7ec4\u7ec7\u3002\u751f\u7269\u6253\u5370\u548c\u751f\u7269\u6750\u6599\u6280\u672f\u53ef\u4ee5\u6784\u5efa\u4e09\u7ef4\u7ec4\u7ec7\u548c\u7c7b\u5668\u5b98\u3002\u8fd9\u4e9b\u65b0\u65b9\u6cd5\u6709\u52a9\u4e8e\u4fee\u590d\u591a\u79cd\u5065\u5eb7\u95ee\u9898\u7684\u7ec4\u7ec7\u635f\u4f24\u3002.<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u75be\u75c5\/\u72b6\u51b5<\/th><th>\u6240\u7528\u5e72\u7ec6\u80de\u7c7b\u578b<\/th><th>\u8bd5\u9a8c\u63cf\u8ff0\/\u7ed3\u679c<\/th><th>\u5730\u7406\u7126\u70b9<\/th><\/tr><tr><td>\u9ec4\u6591\u53d8\u6027<\/td><td>\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u89c6\u7f51\u819c\u7ec6\u80de<\/td><td>\u65e9\u671f\u8bd5\u9a8c\u4e2d\u7684\u5b89\u5168\u79fb\u690d<\/td><td>\u4e9a\u6d32\uff08\u65e5\u672c\uff09<\/td><\/tr><tr><td>\u5e15\u91d1\u68ee\u75c5<\/td><td>\u6765\u81ea hESCs\/hiPSCs \u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143<\/td><td>\u65e9\u671f\u7814\u7a76\u8868\u660e\uff0c\u6539\u8fdb\u7684\u65b9\u6848<\/td><td>\u4e9a\u6d32<\/td><\/tr><tr><td>\u5fc3\u8840\u7ba1\u75be\u75c5<\/td><td>\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u7956\u7ec6\u80de<\/td><td>\u5fc3\u810f\u4fee\u590d\u65b9\u9762\u53d6\u5f97\u4ee4\u4eba\u9f13\u821e\u7684\u6210\u679c<\/td><td>\u4e9a\u6d32<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u5728\u533b\u5b66\u4e0a\u53ef\u80fd\u5bf9\u8bb8\u591a\u4eba\u6709\u6240\u5e2e\u52a9\u3002\u5b83\u4eec\u4fee\u590d\u7ec4\u7ec7\u7684\u80fd\u529b\u6bd4\u6210\u4f53\u5e72\u7ec6\u80de\u66f4\u5f3a\u3002\u8fd9\u4e9b\u5e94\u7528\u8868\u660e\u4e86\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5de8\u5927\u4ef7\u503c\u3002.<\/p><h3 class=\"wp-block-heading\">\u98ce\u9669<\/h3><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u4e5f\u5b58\u5728\u4e00\u4e9b\u98ce\u9669\u3002\u5176\u4e2d\u4e00\u4e2a\u4e3b\u8981\u98ce\u9669\u662f\u7578\u80ce\u7624\u5f62\u6210\u3002\u5982\u679c\u67d0\u4e9b\u7ec6\u80de\u672a\u53d1\u751f\u5206\u5316\uff0c\u79fb\u690d\u540e\u53ef\u80fd\u4f1a\u5f62\u6210\u80bf\u7624\u3002\u5373\u4f7f\u53ea\u67091\u4e07\u4e2a\u672a\u5206\u5316\u7ec6\u80de\uff0c\u4e5f\u53ef\u80fd\u5728\u808c\u8089\u4e2d\u5f15\u53d1\u80bf\u7624\u3002\u7ec6\u80de\u8d8a\u591a\uff0c\u80bf\u7624\u8d8a\u5927\u3002\u7075\u654f\u7684\u68c0\u6d4b\u65b9\u6cd5\u53ef\u4ee5\u5728\u4f7f\u7528\u524d\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u3002\u79d1\u5b66\u5bb6\u4eec\u91c7\u7528\u591a\u79cd\u65b9\u6cd5\u6765\u964d\u4f4e\u8fd9\u4e9b\u98ce\u9669\uff1a<\/p><ul class=\"wp-block-list\">\n<li>\u975e\u6574\u5408\u578b\u57fa\u56e0\u8f6c\u79fb\u7cfb\u7edf\u6709\u52a9\u4e8e\u907f\u514d\u6709\u5bb3\u7684\u57fa\u56e0\u6539\u53d8\u3002.<\/li>\n\n\n\n<li>\u5316\u5b66\u91cd\u7f16\u7a0b\u4f7f\u8be5\u8fc7\u7a0b\u66f4\u5b89\u5168\u3002.<\/li>\n\n\n\n<li>\u53ea\u6709\u5b89\u5168\u3001\u5b8c\u5168\u8f6c\u5316\u8fc7\u7684\u7ec6\u80de\u624d\u4f1a\u7528\u4e8e\u79fb\u690d\u3002.<\/li>\n\n\n\n<li>\u81ea\u6740\u57fa\u56e0\u5728\u5fc5\u8981\u65f6\u53ef\u4ee5\u6467\u6bc1\u80bf\u7624\u7ec6\u80de\u3002.<\/li>\n\n\n\n<li>\u7279\u6b8a\u836f\u7269\u53ef\u4ee5\u6e05\u9664\u672a\u5206\u5316\u7ec6\u80de\u3002.<\/li>\n\n\n\n<li>\u5316\u5b66\u9884\u5904\u7406\u53ef\u4ee5\u964d\u4f4e\u60a3\u764c\u98ce\u9669\u3002.<\/li>\n\n\n\n<li>\u52a8\u7269\u8bd5\u9a8c\u7528\u4e8e\u68c0\u6d4b\u80bf\u7624\uff0c\u7136\u540e\u518d\u7528\u4e8e\u4eba\u4f53\u3002.<\/li>\n<\/ul><p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u6b65\u9aa4\u6709\u52a9\u4e8e\u63d0\u9ad8\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u5b89\u5168\u6027\uff0c\u4e5f\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u8fdb\u884c\u7ec4\u7ec7\u4fee\u590d\u548c\u518d\u751f\u3002.<\/p><p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u5bf9\u79d1\u5b66\u548c\u533b\u5b66\u6765\u8bf4\u975e\u5e38\u7279\u6b8a\u3002\u5b83\u4eec\u51e0\u4e4e\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\u3002\u8fd9\u610f\u5473\u7740\u5b83\u4eec\u53ef\u7528\u4e8e\u7814\u7a76\u75be\u75c5\u3001\u6d4b\u8bd5\u65b0\u836f\u4ee5\u53ca\u4fee\u590d\u53d7\u635f\u7ec4\u7ec7\u3002\u5c71\u4e2d\u4f38\u5f25\u53d1\u73b0\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u540e\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u7814\u7a76\u683c\u5c40\u3002\u79d1\u5b66\u5bb6\u4eec\u5f00\u59cb\u63a2\u7d22\u5982\u4f55\u5c06\u8fd9\u4e9b\u7ec6\u80de\u7528\u4e8e\u6bcf\u4f4d\u60a3\u8005\u3002\u4ed6\u4eec\u4e5f\u5e0c\u671b\u5229\u7528\u8fd9\u4e9b\u7ec6\u80de\u57f9\u80b2\u65b0\u7684\u5668\u5b98\u3002\u76ee\u524d\u7684\u7814\u7a76\u91cd\u70b9\u662f\u4fee\u590d\u5fc3\u810f\u3001\u809d\u810f\u548c\u5927\u8111\u3002 <a target=\"_blank\" href=\"https:\/\/www.lechengmedical.com\/zh\/tag\/clinical-applications\/\" rel=\"noreferrer noopener\">\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u770b\u8d77\u6765\u4e0d\u9519<\/a> \u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u7b49\u75be\u75c5\uff0c\u5168\u7403\u8d8a\u6765\u8d8a\u591a\u7684\u516c\u53f8\u6b63\u5728\u7814\u7a76\u8fd9\u4e9b\u7ec6\u80de\u3002\u7531\u4e8e\u4eba\u4eec\u770b\u5230\u4e86\u8bb8\u591a\u65b0\u7684\u7528\u9014\u548c\u5de8\u5927\u7684\u65b0\u53d1\u73b0\u6f5c\u529b\uff0c\u5e02\u573a\u6b63\u5728\u5feb\u901f\u589e\u957f\u3002.<\/p><figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-orig-src=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/07\/image-11-1-11.webp\" alt=\"\" class=\"lazyload wp-image-306\"><\/figure><blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u8ba4\u4e3a\uff0c\u5982\u679c\u7814\u7a76\u6301\u7eed\u8fdb\u884c\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u5c06\u4ee5\u5168\u65b0\u7684\u65b9\u5f0f\u5e2e\u52a9\u4eba\u4f53\u6108\u5408\u548c\u4fee\u590d\u3002\u8fd9\u4e3a\u8bb8\u591a\u60a3\u6709\u4e0d\u540c\u75be\u75c5\u7684\u4eba\u4eec\u5e26\u6765\u4e86\u5e0c\u671b\u3002.<\/p>\n<\/blockquote><h2 class=\"wp-block-heading\">\u5e38\u95ee\u95ee\u9898<\/h2><div data-schema-only=\"false\" class=\"wp-block-aioseo-faq\"><h3 class=\"aioseo-faq-block-question\">\u591a\u80fd\u5e72\u7ec6\u80de\u4e0e\u5176\u4ed6\u5e72\u7ec6\u80de\u6709\u4f55\u4e0d\u540c\uff1f<\/h3><div class=\"aioseo-faq-block-answer\">\n<p class=\"wp-block-paragraph\">\u591a\u80fd\u5e72\u7ec6\u80de\u51e0\u4e4e\u53ef\u4ee5\u5206\u5316\u6210\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\u3002\u591a\u6f5c\u80fd\u5e72\u7ec6\u80de\u53ea\u80fd\u5206\u5316\u6210\u5c11\u6570\u51e0\u79cd\u7ec6\u80de\u3002\u5355\u80fd\u5e72\u7ec6\u80de\u53ea\u80fd\u5206\u5316\u6210\u4e00\u79cd\u7ec6\u80de\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u4e3a\u79d1\u5b66\u548c\u533b\u5b66\u63d0\u4f9b\u4e86\u66f4\u591a\u9009\u62e9\u3002.<\/p>\n<\/div><\/div><h3 class=\"wp-block-heading\">\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u6cbb\u6108\u75be\u75c5\u5417\uff1f<\/h3><p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u5229\u7528\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u7814\u7a76\u75be\u75c5\uff0c\u5e76\u5c1d\u8bd5\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u4e9b\u7ec6\u80de\u672a\u6765\u6216\u8bb8\u6709\u52a9\u4e8e\u4fee\u590d\u7ec4\u7ec7\u3002\u4e00\u4e9b\u65e9\u671f\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u5728\u5927\u591a\u6570\u7597\u6cd5\u6210\u719f\u4e4b\u524d\uff0c\u8fd8\u9700\u8981\u5f00\u5c55\u66f4\u591a\u7814\u7a76\u3002.<\/p><h3 class=\"wp-block-heading\">\u4f7f\u7528\u591a\u80fd\u5e72\u7ec6\u80de\u662f\u5426\u5b58\u5728\u98ce\u9669\uff1f<\/h3><p class=\"wp-block-paragraph\">\u662f\u7684\uff0c\u5b58\u5728\u4e00\u4e9b\u98ce\u9669\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u5982\u679c\u672a\u80fd\u5b8c\u5168\u5206\u5316\uff0c\u53ef\u80fd\u4f1a\u5f62\u6210\u79f0\u4e3a\u7578\u80ce\u7624\u7684\u80bf\u7624\u3002\u79d1\u5b66\u5bb6\u5728\u5c06\u8fd9\u4e9b\u7ec6\u80de\u79fb\u690d\u7ed9\u4eba\u4f53\u4e4b\u524d\uff0c\u4f1a\u91c7\u7528\u7279\u6b8a\u7684\u68c0\u6d4b\u548c\u5b89\u5168\u63aa\u65bd\u6765\u964d\u4f4e\u8fd9\u79cd\u98ce\u9669\u3002.<\/p><h3 class=\"wp-block-heading\">\u79d1\u5b66\u5bb6\u5982\u4f55\u68c0\u6d4b\u7ec6\u80de\u662f\u5426\u5177\u6709\u591a\u80fd\u6027\uff1f<\/h3><blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u4eec\u4f1a\u5bfb\u627e\u7ec6\u80de\u8868\u9762\u7684\u7279\u6b8a\u6807\u8bb0\u3002\u4ed6\u4eec\u8fd8\u4f1a\u68c0\u6d4b\u8fd9\u4e9b\u7ec6\u80de\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u662f\u5426\u80fd\u591f\u5f62\u6210\u6240\u6709\u4e09\u4e2a\u80da\u5c42\u3002\u6709\u65f6\uff0c\u4ed6\u4eec\u4f1a\u4f7f\u7528\u52a8\u7269\u6765\u89c2\u5bdf\u8fd9\u4e9b\u7ec6\u80de\u662f\u5426\u80fd\u591f\u5206\u5316\u6210\u591a\u79cd\u7ec4\u7ec7\u7c7b\u578b\u3002.<\/p>\n<\/blockquote><h3 class=\"wp-block-heading\">\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u4e8e\u54ea\u91cc\uff1f<\/h3><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u7c7b\u578b<\/th><th>\u6765\u6e90<\/th><\/tr><tr><td>\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09<\/td><td>\u65e9\u671f\u80da\u80ce\uff08\u56ca\u80da\uff09<\/td><\/tr><tr><td>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09<\/td><td>\u91cd\u7f16\u7a0b\u7684\u6210\u5e74\u7ec6\u80de<\/td><\/tr><tr><td>\u80da\u80ce\u751f\u6b96\u7ec6\u80de<\/td><td>\u65e9\u671f\u751f\u6b96\u7ec6\u80de<\/td><\/tr><\/tbody><\/table><\/figure><p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u4f53\u5185\u51e0\u4e4e\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u5177\u6709\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u548c\u591a\u529f\u80fd\u6027\uff0c\u53ef\u7528\u4e8e\u7814\u7a76\u3001\u6cbb\u7597\u548c\u518d\u751f\u533b\u5b66\u3002.<\/p>","protected":false},"author":2,"featured_media":309,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[4],"tags":[60,61,93],"class_list":["post-305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-induced-pluripotency","tag-induced-pluripotent-stem","tag-pluripotent-stem-cells"],"_links":{"self":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts\/305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/comments?post=305"}],"version-history":[{"count":0,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts\/305\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/media\/309"}],"wp:attachment":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/media?parent=305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/categories?post=305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/tags?post=305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}