{"id":207,"date":"2025-05-15T23:11:30","date_gmt":"2025-05-16T06:11:30","guid":{"rendered":"https:\/\/www.lechengmedical.com\/?p=207"},"modified":"2025-05-15T23:11:30","modified_gmt":"2025-05-16T06:11:30","slug":"unleashing-the-potential-of-mesenchymal-stem-cells-in-rheumatic-disease-treatment","status":"publish","type":"post","link":"https:\/\/www.lechengmedical.com\/zh\/unleashing-the-potential-of-mesenchymal-stem-cells-in-rheumatic-disease-treatment\/","title":{"rendered":"\u91ca\u653e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u98ce\u6e7f\u75c5\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b"},"content":{"rendered":"

<\/p>\n

\u98ce\u6e7f\u6027\u75be\u75c5\u662f\u4e00\u7ec4\u4e3b\u8981\u7d2f\u53ca\u5173\u8282\u3001\u808c\u8089\u548c\u7ed3\u7f14\u7ec4\u7ec7\u7684\u75be\u75c5\u3002\u5b83\u4eec\u901a\u5e38\u4ee5\u708e\u75c7\u3001\u75bc\u75db\u548c\u529f\u80fd\u969c\u788d\u4e3a\u7279\u5f81\uff0c\u5e76\u53ef\u80fd\u663e\u8457\u964d\u4f4e\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u548c\u9aa8\u8d28\u758f\u677e\u75c7\u7b49\u75be\u75c5\u5747\u5c5e\u4e8e\u6b64\u7c7b\u3002\u4f20\u7edf\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u4fa7\u91cd\u4e8e\u75c7\u72b6\u63a7\u5236\uff0c\u4f46\u5f80\u5f80\u4f34\u6709\u5404\u79cd\u526f\u4f5c\u7528\uff0c\u4e14\u53ef\u80fd\u65e0\u6cd5\u89e3\u51b3\u75be\u75c5\u7684\u6839\u672c\u539f\u56e0\u3002\u800c\u5e72\u7ec6\u80de\u7597\u6cd5\uff0c\u7279\u522b\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7597\u6cd5\uff0c\u5219\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002.\n<\/p>\n

\u5e72\u7ec6\u80de\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6cbb\u7597\u4e2d\u7684\u6bd4\u8f83\u7814\u7a76<\/h2>\n

\n\u6709\u4e0d\u540c\u7c7b\u578b\u7684 \u5e72\u7ec6\u80de<\/a>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5305\u62ec\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u548c\u6210\u4f53\u5e72\u7ec6\u80de\uff08ASCs\uff09\u3002ESCs\u6765\u6e90\u4e8e\u80da\u80ce\uff0c\u5177\u6709\u5206\u5316\u6210\u4f53\u5185\u4efb\u4f55\u7ec6\u80de\u7c7b\u578b\u7684\u80fd\u529b\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6d89\u53ca\u80da\u80ce\u7834\u574f\u7684\u4f26\u7406\u95ee\u9898\uff0c\u5176\u5e94\u7528\u5907\u53d7\u4e89\u8bae\u3002iPSCs\u662f\u901a\u8fc7\u5c06\u6210\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u56de\u591a\u80fd\u72b6\u6001\u800c\u4ea7\u751f\u7684\u3002\u867d\u7136iPSCs\u907f\u514d\u4e86ESCs\u7684\u4f26\u7406\u95ee\u9898\uff0c\u4f46\u4ecd\u5b58\u5728\u81f4\u7624\u6027\u548c\u514d\u75ab\u6392\u65a5\u7684\u98ce\u9669\u3002\u53e6\u4e00\u65b9\u9762\uff0cASCs\u5b58\u5728\u4e8e\u5404\u79cd\u6210\u4f53\u7ec4\u7ec7\u4e2d\uff0c\u4f8b\u5982\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u548c\u8110\u5e26\u8840\u3002\u5728ASCs\u4e2d\uff0cMSCs\u662f\u6cbb\u7597\u98ce\u6e7f\u6027\u75be\u75c5\u7684\u4e00\u79cd\u7279\u522b\u6709\u5438\u5f15\u529b\u7684\u9009\u62e9\u3002.<\/p>\n

\"Immunomodulatory

\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/p><\/div>\n

\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5177\u6709\u591a\u9879\u4f18\u52bf\u3002\u5b83\u4eec\u6765\u6e90\u5e7f\u6cdb\u4e14\u6613\u4e8e\u83b7\u53d6\uff0c\u514d\u75ab\u539f\u6027\u4f4e\uff0c\u5e76\u4e14\u80fd\u591f\u5206\u6ccc\u591a\u79cd\u5177\u6709\u514d\u75ab\u8c03\u8282\u548c\u6297\u708e\u7279\u6027\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\u3002\u8fd9\u4e9b\u7279\u6027\u4f7f\u5f97\u5b83\u4eec\u66f4\u4e0d\u6613\u5f15\u8d77\u514d\u75ab\u6392\u65a5\uff0c\u66f4\u9002\u5408\u81ea\u4f53\u548c\u5f02\u4f53\u79fb\u690d\uff0c\u8fd9\u5bf9\u4e8e\u6cbb\u7597\u6162\u6027\u98ce\u6e7f\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u98ce\u6e7f\u75c5\u81f3\u5173\u91cd\u8981\u3002.<\/p>\n

\"Biological

\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u751f\u7269\u5b66\u6548\u5e94<\/p><\/div>\n

\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u7279\u5b9a\u98ce\u6e7f\u6027\u75be\u75c5\u4e2d\u7684\u5e94\u7528<\/h2>\n
    \n
  1. \u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09<\/strong>\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u662f\u4e00\u79cd\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u53ef\u7d2f\u53ca\u591a\u4e2a\u5668\u5b98\uff0c\u5305\u62ec\u76ae\u80a4\u3001\u5173\u8282\u3001\u80be\u810f\u548c\u5fc3\u810f\u3002\u7531\u4e8e\u5176\u53d1\u75c5\u673a\u5236\u590d\u6742\u4e14\u5668\u5b98\u635f\u4f24\u98ce\u9669\u9ad8\uff0c\u6cbb\u7597\u6781\u5177\u6311\u6218\u6027\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u901a\u8fc7\u8c03\u8282T\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u529f\u80fd\u6765\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u51cf\u5c11\u81ea\u8eab\u6297\u4f53\u7684\u4ea7\u751f\u3002\u5728\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7MSC\u6cbb\u7597\u7684SLE\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\u6709\u6240\u6539\u5584\uff0c\u4f8b\u5982\u75be\u75c5\u6d3b\u52a8\u8bc4\u5206\u964d\u4f4e\u548c\u5668\u5b98\u529f\u80fd\u6539\u5584\u3002\u4f8b\u5982\uff0c\u4e00\u540d\u60a3\u6709\u4e25\u91cd\u72fc\u75ae\u6027\u80be\u708e\u7684\u60a3\u8005\u5728\u63a5\u53d7MSC\u6cbb\u7597\u540e\u80be\u529f\u80fd\u663e\u8457\u6539\u5584\u3002.<\/li>\n
  2. \u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09<\/strong>\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u662f\u4e00\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u5173\u8282\u6162\u6027\u708e\u75c7\uff0c\u6700\u7ec8\u5bfc\u81f4\u5173\u8282\u7834\u574f\u548c\u529f\u80fd\u969c\u788d\u3002\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u65e8\u5728\u63a7\u5236\u708e\u75c7\uff0c\u4f46\u957f\u671f\u7597\u6548\u5f80\u5f80\u6709\u9650\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u80fd\u591f\u5f52\u5de2\u81f3\u708e\u75c7\u5173\u8282\uff0c\u5206\u6ccc\u6297\u708e\u56e0\u5b50\uff0c\u5e76\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u3002\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0cMSC\u7597\u6cd5\u53ef\u4ee5\u51cf\u8f7bRA\u60a3\u8005\u7684\u5173\u8282\u80bf\u80c0\u548c\u75bc\u75db\uff0c\u5e76\u6539\u5584\u5173\u8282\u529f\u80fd\u3002.<\/li>\n
  3. \u5f3a\u76f4\u6027\u810a\u67f1\u708e\uff08AS\uff09<\/strong>\u5f3a\u76f4\u6027\u810a\u67f1\u708e\uff08AS\uff09\u662f\u4e00\u79cd\u4e3b\u8981\u7d2f\u53ca\u810a\u67f1\u548c\u9ab6\u9ac2\u5173\u8282\u7684\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u4f1a\u5bfc\u81f4\u75bc\u75db\u3001\u50f5\u786c\u548c\u8fdb\u884c\u6027\u810a\u67f1\u7578\u5f62\u3002\u6cbb\u7597\u7684\u96be\u70b9\u5728\u4e8e\u96be\u4ee5\u9006\u8f6c\u5173\u8282\u635f\u4f24\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5177\u6709\u51cf\u8f7b\u708e\u75c7\u548c\u4fc3\u8fdb\u9aa8\u9abc\u53ca\u8f6f\u9aa8\u4fee\u590d\u7684\u6f5c\u529b\u3002\u4e00\u4e9b\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u6ce8\u5c04MSCs\u53ef\u4ee5\u7f13\u89e3AS\u60a3\u8005\u7684\u75bc\u75db\u5e76\u6539\u5584\u5176\u810a\u67f1\u6d3b\u52a8\u5ea6\u3002.<\/li>\n
  4. \u9aa8\u5173\u8282\u708e\uff08OA\uff09<\/strong>\u9aa8\u5173\u8282\u708e\uff08OA\uff09\u662f\u4e00\u79cd\u9000\u884c\u6027\u5173\u8282\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u5173\u8282\u8f6f\u9aa8\u548c\u4e0b\u65b9\u9aa8\u9abc\u7684\u7834\u574f\u3002\u5b83\u662f\u8001\u5e74\u4eba\u75bc\u75db\u548c\u529f\u80fd\u969c\u788d\u7684\u5e38\u89c1\u539f\u56e0\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u5206\u5316\u4e3a\u8f6f\u9aa8\u7ec6\u80de\u5e76\u5206\u6ccc\u7ec6\u80de\u5916\u57fa\u8d28\u6210\u5206\uff0c\u4ece\u800c\u5e2e\u52a9\u4fee\u590d\u53d7\u635f\u8f6f\u9aa8\u3002\u5728\u4e00\u4e2a\u4e34\u5e8a\u6848\u4f8b\u4e2d\uff0c\u4e00\u540d\u9aa8\u5173\u8282\u708e\u60a3\u8005\u5728\u63a5\u53d7\u57fa\u4e8eMSCs\u7684\u6cbb\u7597\u540e\uff0c\u5173\u8282\u75bc\u75db\u51cf\u8f7b\uff0c\u6d3b\u52a8\u80fd\u529b\u5f97\u5230\u6539\u5584\u3002.<\/li>\n
  5. \u9aa8\u8d28\u758f\u677e\u75c7\uff08OP\uff09<\/strong>\u9aa8\u8d28\u758f\u677e\u75c7\uff08OP\uff09\u662f\u4e00\u79cd\u4ee5\u9aa8\u91cf\u51cf\u5c11\u548c\u9aa8\u7ec4\u7ec7\u5fae\u7ed3\u6784\u9000\u5316\u4e3a\u7279\u5f81\u7684\u75be\u75c5\uff0c\u4f1a\u5bfc\u81f4\u9aa8\u6298\u98ce\u9669\u589e\u52a0\u3002\u4f20\u7edf\u6cbb\u7597\u4e3b\u8981\u96c6\u4e2d\u4e8e\u9632\u6b62\u9aa8\u8d28\u8fdb\u4e00\u6b65\u6d41\u5931\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\uff0c\u800c\u6210\u9aa8\u7ec6\u80de\u8d1f\u8d23\u9aa8\u9abc\u5f62\u6210\u3002\u521d\u6b65\u7814\u7a76\u8868\u660e\uff0cMSCs\u7597\u6cd5\u53ef\u80fd\u63d0\u9ad8\u9aa8\u8d28\u758f\u677e\u75c7\u60a3\u8005\u7684\u9aa8\u5bc6\u5ea6\u548c\u9aa8\u5f3a\u5ea6\u3002.<\/li>\n
  6. \u5e72\u71e5\u7efc\u5408\u5f81\uff08SS\uff09<\/strong>\u5e72\u71e5\u7efc\u5408\u5f81\uff08SS\uff09\u662f\u4e00\u79cd\u5f71\u54cd\u5916\u5206\u6ccc\u817a\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u4f1a\u5bfc\u81f4\u773c\u5e72\u548c\u53e3\u5e72\u3002\u6cbb\u7597\u4e3b\u8981\u4ee5\u5bf9\u75c7\u6cbb\u7597\u4e3a\u4e3b\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u5e76\u4fc3\u8fdb\u53d7\u635f\u817a\u4f53\u7ec4\u7ec7\u7684\u518d\u751f\u3002\u4e00\u4e9b\u5c0f\u89c4\u6a21\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u79f0\uff0cMSCs\u6cbb\u7597\u540e\u5e72\u71e5\u75c7\u72b6\u6709\u6240\u6539\u5584\u3002.<\/li>\n
  7. \u514b\u7f57\u6069\u75c5\uff08CD\uff09<\/strong>\u514b\u7f57\u6069\u75c5\uff08CD\uff09\u662f\u4e00\u79cd\u6162\u6027\u708e\u75c7\u6027\u80a0\u75c5\uff0c\u53ef\u7d2f\u53ca\u80c3\u80a0\u9053\u7684\u4efb\u4f55\u90e8\u4f4d\u3002\u7531\u4e8e\u5176\u53cd\u590d\u53d1\u4f5c\u7684\u7279\u6027\uff0c\u6cbb\u7597\u9887\u5177\u6311\u6218\u6027\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u80fd\u591f\u8c03\u8282\u80a0\u9053\u514d\u75ab\u7cfb\u7edf\u5e76\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u3002\u5728\u4e00\u4e9b\u4e34\u5e8a\u75c5\u4f8b\u4e2d\uff0cCD\u60a3\u8005\u5728\u63a5\u53d7MSCs\u8f93\u6ce8\u540e\uff0c\u708e\u75c7\u51cf\u8f7b\uff0c\u80a0\u9053\u529f\u80fd\u5f97\u5230\u6539\u5584\u3002.<\/li>\n
  8. \u7ea4\u7ef4\u808c\u75db\uff08FM\uff09<\/strong>\u7ea4\u7ef4\u808c\u75db\uff08FM\uff09\u662f\u4e00\u79cd\u6162\u6027\u75bc\u75db\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u5168\u8eab\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3001\u75b2\u52b3\u548c\u7761\u7720\u969c\u788d\u3002\u5176\u75c5\u56e0\u5c1a\u672a\u5b8c\u5168\u660e\u786e\uff0c\u6cbb\u7597\u9009\u62e9\u4e5f\u6709\u9650\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u80fd\u5728\u8c03\u8282\u75bc\u75db\u76f8\u5173\u795e\u7ecf\u901a\u8def\u548c\u51cf\u8f7b\u708e\u75c7\u65b9\u9762\u53d1\u6325\u4f5c\u7528\u3002\u5c3d\u7ba1 \u4e34\u5e8a\u7814\u7a76<\/a> \u867d\u7136\u4ecd\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u4f46\u4e00\u4e9b\u60a3\u8005\u5728\u63a5\u53d7 MSC \u6cbb\u7597\u540e\u62a5\u544a\u75bc\u75db\u5f97\u5230\u7f13\u89e3\u3002.<\/li>\n
  9. \u7cfb\u7edf\u6027\u786c\u5316\u75c7\uff08SSc\uff09<\/strong>\u7cfb\u7edf\u6027\u786c\u5316\u75c7\uff08SSc\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u76ae\u80a4\u548c\u5185\u810f\u5668\u5b98\u8fc7\u5ea6\u7ea4\u7ef4\u5316\u3002\u7531\u4e8e\u7ea4\u7ef4\u5316\u7684\u8fdb\u884c\u6027\u53d1\u5c55\uff0c\u6cbb\u7597\u5341\u5206\u56f0\u96be\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u6291\u5236\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u548c\u80f6\u539f\u86cb\u767d\u5408\u6210\uff0c\u4e00\u4e9b\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0cMSCs\u7597\u6cd5\u53ef\u80fd\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\uff0c\u6539\u5584\u76ae\u80a4\u539a\u5ea6\u548c\u5668\u5b98\u529f\u80fd\u3002.<\/li>\n
  10. \u76ae\u808c\u708e\uff08DM\uff09\u548c\u591a\u53d1\u6027\u808c\u708e\uff08PM\uff09<\/strong>\u76ae\u808c\u708e\uff08DM\uff09\u548c\u591a\u53d1\u6027\u808c\u708e\uff08PM\uff09\u662f\u708e\u75c7\u6027\u808c\u75c5\uff0c\u5176\u7279\u5f81\u662f\u808c\u8089\u65e0\u529b\u548c\u708e\u75c7\u3002\u6cbb\u7597\u901a\u5e38\u9700\u8981\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\uff0c\u4f46\u8fd9\u4e9b\u836f\u7269\u526f\u4f5c\u7528\u663e\u8457\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u5e76\u4fc3\u8fdb\u808c\u8089\u4fee\u590d\u3002\u5728\u4e00\u4e9b\u4e34\u5e8a\u75c5\u4f8b\u4e2d\uff0cDM\u548cPM\u60a3\u8005\u5728\u63a5\u53d7MSC\u6cbb\u7597\u540e\uff0c\u808c\u8089\u529b\u91cf\u6709\u6240\u6539\u5584\uff0c\u808c\u8089\u708e\u75c7\u4e5f\u6709\u6240\u51cf\u8f7b\u3002.<\/li>\n<\/ol>\n

    \n\u603b\u4e4b\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u98ce\u6e7f\u6027\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5176\u72ec\u7279\u7684\u514d\u75ab\u8c03\u8282\u548c\u518d\u751f\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u4f20\u7edf\u7597\u6cd5\u7684\u6709\u529b\u66ff\u4ee3\u65b9\u6848\u3002\u5c3d\u7ba1\u8fd8\u9700\u8981\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6765\u5145\u5206\u8bc1\u5b9e\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4f46\u73b0\u6709\u8bc1\u636e\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u672a\u6765\u6709\u671b\u5f7b\u5e95\u6539\u53d8\u8fd9\u4e9b\u81f4\u6b8b\u6027\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u5f0f\u3002.<\/p>\n

     <\/p>","protected":false},"excerpt":{"rendered":"

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