{"id":155,"date":"2025-04-23T23:27:23","date_gmt":"2025-04-24T06:27:23","guid":{"rendered":"https:\/\/www.lechengmedical.com\/?p=155"},"modified":"2025-04-23T23:27:23","modified_gmt":"2025-04-24T06:27:23","slug":"stem-cell-differentiation-the-science-behind-cellular-reprogramming-in-medicine","status":"publish","type":"post","link":"https:\/\/www.lechengmedical.com\/zh\/stem-cell-differentiation-the-science-behind-cellular-reprogramming-in-medicine\/","title":{"rendered":"\u5e72\u7ec6\u80de\u5206\u5316\uff1a\u533b\u5b66\u4e2d\u7ec6\u80de\u91cd\u7f16\u7a0b\u80cc\u540e\u7684\u79d1\u5b66\u539f\u7406"},"content":{"rendered":"<?xml encoding=\"UTF-8\"><p class=\"wp-block-paragraph\">\u5e72\u7ec6\u80de\u4e0e\u5176\u4ed6\u7ec6\u80de\u7684\u533a\u522b\u662f\u6211\u5728\u533b\u5b66\u7814\u7a76\u4e2d\u6700\u5f15\u4eba\u5165\u80dc\u7684\u8fc7\u7a0b\u4e4b\u4e00\u3002\u8fd9\u4e9b\u201c\u4e07\u80fd\u7ec6\u80de\u201d\u662f\u4eba\u4f53\u5185\u552f\u4e00\u80fd\u591f\u5206\u5316\u6210200\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7279\u5316\u7ec6\u80de\u7684\u7ec6\u80de\u3002\u5b83\u4eec\u975e\u5e38\u795e\u5947\u2014\u2014\u4e0e\u5bff\u547d\u6709\u9650\u7684\u666e\u901a\u7ec6\u80de\u4e0d\u540c\uff0c\u5e72\u7ec6\u80de\u80fd\u591f\u4e0d\u65ad\u66f4\u65b0\u5e76\u590d\u5236\u81ea\u8eab\u3002.<\/p><p class=\"wp-block-paragraph\">\u5e72\u7ec6\u80de\u662f\u6784\u6210\u6211\u4eec\u8eab\u4f53\u7684\u57fa\u672c\u5355\u5143\u3002\u4eba\u4f53\u5229\u7528\u5b83\u4eec\u4f5c\u4e3a\u5929\u7136\u7684\u4fee\u590d\u7cfb\u7edf\u3002\u9020\u8840\u5e72\u7ec6\u80de\u7ef4\u6301\u8840\u6db2\u548c\u514d\u75ab\u7ec6\u80de\u7684\u751f\u6210\uff0c\u800c <a href=\"https:\/\/www.lechengmedical.com\/zh\/what-makes-mesenchymal-stem-cells-truly-remarkable\/\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/a> \u7ec6\u80de\u652f\u6491\u7740\u9aa8\u9abc\u3001\u8f6f\u9aa8\u3001\u808c\u8089\u548c\u8102\u80aa\u3002\u6211\u6700\u559c\u6b22\u8fd9\u4e9b\u7ec6\u80de\u7684\u4e00\u70b9\u662f\u5b83\u4eec\u5177\u6709\u5206\u5316\u6210\u4e0d\u540c\u7c7b\u578b\u7ec6\u80de\u7684\u80fd\u529b\u2014\u2014\u4ece\u8840\u7ec6\u80de\u5230\u795e\u7ecf\u7ec6\u80de\u518d\u5230\u5fc3\u808c\u7ec6\u80de\u3002\u8fd9\u4f7f\u5f97\u5b83\u4eec\u6210\u4e3a\u83b7\u53d6\u533b\u5b66\u7814\u7a76\u548c\u6cbb\u7597\u89c1\u89e3\u7684\u7edd\u4f73\u9014\u5f84\u3002.<\/p><p class=\"wp-block-paragraph\">\u5e72 <a href=\"https:\/\/www.lechengmedical.com\/zh\/stem-cell-therapy-for-chronic-obstructive-pulmonary-disease-a-paradigm-shift-in-regenerative-medicine\/\">\u7ec6\u80de\u7597\u6cd5<\/a> \u8fd9\u4e9b\u7ec6\u80de\u7597\u6cd5\u5728\u6cbb\u7597\u5404\u79cd\u75be\u75c5\u65b9\u9762\u5c55\u73b0\u51fa\u5de8\u5927\u6f5c\u529b\u3002\u8fd9\u4e00\u70b9\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u7ea6\u6709 60% \u7684\u7f8e\u56fd\u6210\u5e74\u4eba\u60a3\u6709\u6162\u6027\u75be\u75c5\uff0c\u8fd9\u8868\u660e\u4eba\u4eec\u5bf9\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u6709\u7740\u8feb\u5207\u7684\u9700\u6c42\u3002\u6162\u6027\u75be\u75c5\u7684\u79cd\u7c7b\u8fd8\u5728\u4e0d\u65ad\u589e\u52a0\u2014\u2014\u4ece\u5173\u8282\u708e\u548c\u591a\u53d1\u6027\u786c\u5316\u75c7\u5230\u5404\u79cd\u764c\u75c7\u548c\u5fc3\u810f\u75c5\u3002\u5f53\u5e38\u89c4\u7597\u6cd5\u65e0\u6548\u65f6\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7597\u6cd5\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002.<\/p><p class=\"wp-block-paragraph\">\u672c\u6587\u5c06\u6df1\u5165\u63a2\u8ba8\u7ec6\u80de\u91cd\u7f16\u7a0b\u7684\u79d1\u5b66\u539f\u7406\uff0c\u4ee5\u53ca\u79d1\u5b66\u5bb6\u5982\u4f55\u5229\u7528\u5e72\u7ec6\u80de\u6539\u53d8\u533b\u5b66\u3002\u6211\u4eec\u5c06\u7814\u7a76\u9a71\u52a8\u7ec6\u80de\u53d1\u80b2\u7684\u673a\u5236\u3001\u5f15\u5bfc\u7ec6\u80de\u751f\u957f\u7684\u6700\u5feb\u65b9\u6cd5\uff0c\u4ee5\u53ca\u6b63\u5728\u6539\u5584\u60a3\u8005\u62a4\u7406\u7684\u4ee4\u4eba\u632f\u594b\u7684\u4e34\u5e8a\u5e94\u7528\u3002.<\/p><h2 class=\"wp-block-heading\">\u5e72\u7ec6\u80de\u5206\u5316\u7684\u5206\u5b50\u57fa\u7840<\/h2><figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"812\" src=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1-1024x812.png\" data-orig-src=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1-1024x812.png\" alt=\"\" class=\"lazyload wp-image-157\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271024%27%20height%3D%27812%27%20viewBox%3D%270%200%201024%20812%27%3E%3Crect%20width%3D%271024%27%20height%3D%27812%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1-300x238.png 300w, https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1-768x609.png 768w, https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1-1024x812.png 1024w, https:\/\/www.lechengmedical.com\/wp-content\/uploads\/2025\/04\/cc871bd2-378e-46f6-a7c7-3128cd0beefe-1.png 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><p class=\"wp-block-paragraph\"><sub>\u56fe\u7247\u6765\u6e90\uff1a <\/sub><a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\"><sub>\u4e34\u5e8a\u8868\u89c2\u9057\u4f20\u5b66 \u2013 \u751f\u7269\u533b\u5b66\u4e2d\u5fc3<\/sub><\/a><\/p><p class=\"wp-block-paragraph\">\u5e72\u7ec6\u80de\u5206\u79bb\u7684\u5206\u5b50\u590d\u6742\u6027\u53d6\u51b3\u4e8e\u7cbe\u7ec6\u7684\u9057\u4f20\u548c\u8868\u89c2\u9057\u4f20\u673a\u5236\uff0c\u8fd9\u4e9b\u673a\u5236\u5c06\u672a\u5206\u5316\u7684\u7ec6\u80de\u8f6c\u5316\u4e3a\u529f\u80fd\u6027\u7684\u3001\u7ec4\u7ec7\u7279\u5f02\u6027\u7684\u7ec6\u80de\u3002\u79d1\u5b66\u5bb6\u4eec\u73b0\u5728\u8ba4\u4e3a\uff0c\u7406\u89e3\u8fd9\u4e9b\u673a\u5236\u5bf9\u4e8e\u63a8\u8fdb\u518d\u751f\u533b\u5b66\u7684\u53d1\u5c55\u81f3\u5173\u91cd\u8981\u3002.<\/p><h3 class=\"wp-block-heading\">\u591a\u80fd\u6027\u4e0e\u591a\u91cd\u6f5c\u80fd\uff1a\u4e3b\u8981\u533a\u522b<\/h3><p class=\"wp-block-paragraph\">\u5e72\u7ec6\u80de\u7684\u5206\u79bb\u80fd\u529b\u51b3\u5b9a\u4e86\u5176\u7ec6\u80de\u5206\u5316\u6f5c\u80fd\u3002\u591a\u80fd\u5e72\u7ec6\u80de <a href=\"https:\/\/www.lechengmedical.com\/zh\/stem-cells-and-immune-cells-guardians-and-architects-of-human-health\/\">\u5e72\u7ec6\u80de<\/a> \u591a\u80fd\u5e72\u7ec6\u80de\uff08PSCs\uff09\u53ef\u4ee5\u5206\u5316\u6210\u6765\u81ea\u6240\u6709\u4e09\u4e2a\u80da\u5c42\u2014\u2014\u5916\u80da\u5c42\u3001\u4e2d\u80da\u5c42\u548c\u5185\u80da\u5c42\u7684\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u4e0d\u80fd\u5f62\u6210\u80ce\u76d8\u6216\u8110\u5e26\u7b49\u80da\u5916\u7ec4\u7ec7\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u53ea\u80fd\u5206\u5316\u6210\u7279\u5b9a\u8c31\u7cfb\u5185\u5bc6\u5207\u76f8\u5173\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u9020\u8840\u5e72\u7ec6\u80de\uff08HSCs\uff09\u4e13\u95e8\u4ea7\u751f\u5404\u79cd\u8840\u7ec6\u80de\uff0c\u800c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5219\u53ef\u5206\u5316\u6210\u9aa8\u7ec6\u80de\u3001\u8f6f\u9aa8\u7ec6\u80de\u3001\u808c\u8089\u7ec6\u80de\u548c\u8102\u80aa\u7ec6\u80de\u3002\u8fd9\u79cd\u5206\u5316\u6f5c\u80fd\u7684\u6839\u672c\u5dee\u5f02\u51b3\u5b9a\u4e86\u6bcf\u79cd\u5e72\u7ec6\u80de\u7c7b\u578b\u53ef\u4ee5\u6cbb\u7597\u54ea\u4e9b\u75be\u75c5\u3002.<\/p><h3 class=\"wp-block-heading\">\u8c31\u7cfb\u5b9a\u5411\u4e2d\u7684\u8f6c\u5f55\u56e0\u5b50<\/h3><p class=\"wp-block-paragraph\">\u8f6c\u5f55\u56e0\u5b50\uff08TFs\uff09\u5728\u5e72\u7ec6\u80de\u5206\u79bb\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u5173\u952e\u8c03\u63a7\u4f5c\u7528\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u6838\u5fc3\u8f6c\u5f55\u56e0\u5b50\u5305\u62ecOCT4\u3001SOX2\u548cNANOG\uff0c\u5b83\u4eec\u7ef4\u6301\u7740\u5e72\u7ec6\u80de\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u3002\u8fd9\u4e9b\u56e0\u5b50\u901a\u8fc7\u4e0e\u7279\u5b9a\u7684DNA\u5e8f\u5217\u7ed3\u5408\uff0c\u8c03\u63a7\u7ef4\u6301\u5e72\u7ec6\u80de\u7279\u6027\u6240\u5fc5\u9700\u7684\u57fa\u56e0\u8868\u8fbe\u3002.<\/p><p class=\"wp-block-paragraph\">\u4e0d\u540c\u7684\u8f6c\u5f55\u56e0\u5b50\u5728\u8c31\u7cfb\u5206\u5316\u8fc7\u7a0b\u4e2d\u51b3\u5b9a\u7ec6\u80de\u547d\u8fd0\u3002\u4f8b\u5982\uff1a<\/p><ul class=\"wp-block-list\">\n<li>RUNX2 \u548c Osterix \u5f15\u5bfc\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5411\u9aa8\u5f62\u6210\u65b9\u5411\u53d1\u5c55 <\/li>\n\n\n\n<li>PPAR\u03b3 \u6307\u5bfc\u8102\u80aa\u751f\u6210<\/li>\n\n\n\n<li>SOX9 \u63a7\u5236\u8f6f\u9aa8\u7ec6\u80de\u5206\u5316 <\/li>\n\n\n\n<li>GATA-1\u3001GATA-2 \u548c PU.1 \u8c03\u63a7\u9020\u8840\u53d1\u80b2 <\/li>\n<\/ul><p class=\"wp-block-paragraph\">\u7814\u7a76\u8868\u660e\uff0c\u5373\u4f7f\u6fc0\u6d3b\u5355\u4e2a\u8c31\u7cfb\u7279\u5f02\u6027\u8f6c\u5f55\u56e0\u5b50\uff0c\u4e5f\u80fd\u5c06\u7956\u7ec6\u80de\u8f6c\u5316\u4e3a\u4e0d\u540c\u7684\u8c31\u7cfb\u3002.<\/p><h3 class=\"wp-block-heading\">\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7<\/h3><p class=\"wp-block-paragraph\">\u8868\u89c2\u9057\u4f20\u673a\u5236\u5bf9\u5e72\u7ec6\u80de\u547d\u8fd0\u7684\u5f71\u54cd\u8fdc\u8d85\u8f6c\u5f55\u56e0\u5b50\u3002DNA\u7532\u57fa\u5316\u3001\u7ec4\u86cb\u767d\u4fee\u9970\u548c\u975e\u7f16\u7801RNA\u8c03\u63a7\u6784\u6210\u4e86\u8fd9\u4e9b\u673a\u5236\u3002.<\/p><p class=\"wp-block-paragraph\">\u4e0e\u81ea\u6211\u66f4\u65b0\u76f8\u5173\u7684\u57fa\u56e0\u9010\u6e10\u6c89\u9ed8\uff0c\u800c\u8c31\u7cfb\u7279\u5f02\u6027\u57fa\u56e0\u5728\u5206\u5316\u8fc7\u7a0b\u4e2d\u88ab\u6fc0\u6d3b\u3002CpG\u4f4d\u70b9DNA\u7532\u57fa\u5316\u6a21\u5f0f\u7684\u52a8\u6001\u53d8\u5316\u548c\u7ec4\u86cb\u767d\u7684\u4fee\u9970\u9a71\u52a8\u7740\u8fd9\u4e00\u8fc7\u7a0b\u3002\u7ec4\u86cb\u767dH3K4\u7684\u7532\u57fa\u5316\u6fc0\u6d3b\u57fa\u56e0\uff0c\u800cH3K27\u7684\u7532\u57fa\u5316\u5219\u4f7f\u5176\u6c89\u9ed8\u3002\u5177\u6709\u76f8\u53cd\u6d3b\u6027\u7684\u67d3\u8272\u8d28\u4fee\u9970\u9176\u5b9e\u73b0\u4e86\u7ec6\u80de\u91cd\u7f16\u7a0b\u6240\u9700\u7684\u7cbe\u786e\u4e14\u53ef\u9006\u7684\u8c03\u63a7\u3002.<\/p><h2 class=\"wp-block-heading\">\u7ec6\u80de\u91cd\u7f16\u7a0b\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09<\/h2><p class=\"wp-block-paragraph\">\u7ec6\u80de\u91cd\u7f16\u7a0b\u5f7b\u5e95\u6539\u53d8\u4e86\u6211\u4eec\u5bf9\u7ec6\u80de\u547d\u8fd0\u53ef\u5851\u6027\u7684\u7406\u89e3\uff0c\u5e76\u4e3a\u518d\u751f\u533b\u5b66\u5f00\u8f9f\u4e86\u65b0\u7684\u53ef\u80fd\u6027\u3002\u672c\u8282\u5c06\u6df1\u5165\u63a2\u8ba8\u5982\u4f55\u901a\u8fc7\u57fa\u56e0\u64cd\u4f5c\u4f7f\u5206\u5316\u7ec6\u80de\u9006\u8f6c\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u72b6\u6001\u3002.<\/p><h3 class=\"wp-block-heading\">\u5c71\u4e2d\u56e0\u5b50\u548ciPSC\u751f\u6210<\/h3><p class=\"wp-block-paragraph\">\u5c71\u4e2d\u4f38\u5f25\u548c\u9ad8\u6865\u548c\u4fca\u57282006\u5e74\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u4ed6\u4eec\u5c06\u5c0f\u9f20\u6210\u7ea4\u7ef4\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3a\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u3002 <a href=\"https:\/\/www.lechengmedical.com\/zh\/stem-cells-and-immune-cells-guardians-and-architects-of-human-health\">\u5e72\u7ec6\u80de<\/a>\u4ed6\u4eec\u53d1\u73b0\u4e86\u56db\u79cd\u5173\u952e\u7684\u8f6c\u5f55\u56e0\u5b50\u2014\u2014Oct3\/4\u3001Sox2\u3001Klf4 \u548c c-Myc\u2014\u2014\u73b0\u5728\u88ab\u79f0\u4e3a\u5c71\u4e2d\u56e0\u5b50\uff0c\u8fd9\u4e9b\u56e0\u5b50\u53ef\u4ee5\u5c06\u4f53\u7ec6\u80de\u8f6c\u5316\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u30022007 \u5e74\uff0c\u4ed6\u4eec\u6210\u529f\u5730\u5229\u7528\u6210\u4eba\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u5b9e\u73b0\u4e86\u8fd9\u4e00\u76ee\u6807\u3002 .<\/p><p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u5c71\u4e2d\u56e0\u5b50\u89e6\u53d1\u7ef4\u6301\u591a\u80fd\u6027\u7684\u5173\u952e\u53d1\u80b2\u4fe1\u53f7\u901a\u8def\u3002\u5177\u4f53\u800c\u8a00\uff1a<\/p><ul class=\"wp-block-list\">\n<li>Oct4 \u548c Sox2 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class=\"wp-block-paragraph\">\u4e24\u79cd\u65b9\u6cd5\u90fd\u80fd\u5236\u5907\u60a3\u8005\u7279\u5f02\u6027\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u3002\u4f53\u7ec6\u80de\u6838\u79fb\u690d\uff08SCNT\uff09\u5728\u591a\u79cd\u810a\u690e\u52a8\u7269\u4e2d\u6548\u679c\u826f\u597d\uff0c\u4f46\u9762\u4e34\u6280\u672f\u3001\u6cd5\u5f8b\u548c\u4f26\u7406\u65b9\u9762\u7684\u6311\u6218\u3002\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u91cd\u7f16\u7a0b\u6280\u672f\u867d\u7136\u64cd\u4f5c\u66f4\u7b80\u4fbf\uff0c\u4f46\u6548\u7387\u548c\u901f\u5ea6\u8fdc\u4e0d\u53caSCNT\u3002.<\/p><h3 class=\"wp-block-heading\">\u91cd\u7f16\u7a0b\u7ec6\u80de\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\u98ce\u9669<\/h3><p class=\"wp-block-paragraph\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u5c55\u73b0\u51fa\u5e94\u7528\u524d\u666f\uff0c\u4f46\u4e5f\u5f15\u53d1\u4e86\u4eba\u4eec\u5bf9\u5176\u57fa\u56e0\u7ec4\u5b8c\u6574\u6027\u7684\u62c5\u5fe7\u3002\u6bd4\u8f83\u57fa\u56e0\u7ec4\u6742\u4ea4\u5206\u6790\u663e\u793a\uff0c\u91cd\u7f16\u7a0b\u7ec6\u80de\u4e2d\u5b58\u5728\u7f3a\u5931\u548c\u6269\u589e\u3002\u8fd9\u4e9b\u7279\u5f81\u8868\u660e\uff0c\u764c\u57fa\u56e0\u8bf1\u5bfc\u4e86DNA\u590d\u5236\u5e94\u6fc0\u3002\u57fa\u56e0\u7ec4\u53d8\u5316\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8ec-Myc\u7684\u8868\u8fbe\u3002.<\/p><p class=\"wp-block-paragraph\">\u8be5\u65b9\u6cd5\u6548\u7387\u8f83\u4f4e\uff08\u7ea60.01\u20130.1%\uff09\uff0c\u8868\u660e\u8be5\u6280\u672f\u5b58\u5728\u95ee\u9898\u3002\u5f53\u79d1\u5b66\u5bb6\u963b\u65adp53\u7b49\u6291\u764c\u57fa\u56e0\u65f6\uff0cp53\u901a\u8def\u53d7\u635f\u7684\u7ec6\u80de\u66f4\u5bb9\u6613\u88ab\u91cd\u7f16\u7a0b\u3002\u65e9\u671f\u4f20\u4ee3\u7684iPSCs\u4e5f\u6bd4\u4e2d\u671f\u4f20\u4ee3\u7ec6\u80de\u6216\u6210\u7ea4\u7ef4\u7ec6\u80de\u542b\u6709\u66f4\u591a\u7684\u62f7\u8d1d\u6570\u53d8\u5f02\u3002.<\/p><h2 class=\"wp-block-heading\">\u6750\u6599\u4e0e\u65b9\u6cd5\uff1a\u57f9\u517b\u548c\u5f15\u5bfc\u5206\u5316<\/h2><p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u9700\u8981\u7cbe\u786e\u63a7\u5236\u7ec6\u80de\u73af\u5883\u624d\u80fd\u6709\u6548\u5730\u8bf1\u5bfc\u5e72\u7ec6\u80de\u5206\u5316\u3002\u8fc7\u53bb\u51e0\u5e74\u91cc\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u66f4\u5148\u8fdb\u7684\u65b9\u6cd5\u6765\u57f9\u517b\u548c\u5f15\u5bfc\u8fd9\u4e9b\u591a\u529f\u80fd\u7ec6\u80de\u7684\u53d1\u80b2\u3002.<\/p><h3 class=\"wp-block-heading\">\u7528\u4e8e\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u65e0\u9972\u517b\u5c42\u57f9\u517b\u7cfb\u7edf<\/h3><p class=\"wp-block-paragraph\">\u5c0f\u9f20\u80da\u80ce\u6210\u7ea4\u7ef4\u7ec6\u80de (MEF) \u662f\u4f20\u7edf\u5e72\u7ec6\u80de\u57f9\u517b\u7684\u57fa\u7840\u3002\u8fd9\u4e9b\u7ec6\u80de\u5206\u6ccc\u91cd\u8981\u7684\u751f\u957f\u56e0\u5b50\uff0c\u4f8b\u5982 TGF\u03b2\u3001\u6fc0\u6d3b\u7d20 A \u548c\u7ec6\u80de\u5916\u57fa\u8d28\u3002\u79d1\u5b66\u5bb6\u4eec\u5229\u7528 Matrigel \u5f00\u53d1\u4e86\u65e0\u9700\u9972\u517b\u5c42\u7684\u66ff\u4ee3\u57f9\u517b\u65b9\u6cd5\u3002Matrigel \u542b\u6709\u5c42\u7c98\u8fde\u86cb\u767d\u3001IV \u578b\u80f6\u539f\u86cb\u767d\u548c\u786b\u9178\u809d\u7d20\u86cb\u767d\u805a\u7cd6\u3002Matrigel \u53ef\u901a\u8fc7\u7279\u5b9a\u7684\u57f9\u517b\u57fa\u914d\u65b9\u652f\u6301\u5e72\u7ec6\u80de\u751f\u957f\uff0c\u662f\u9996\u6279\u66ff\u4ee3\u9972\u517b\u5c42\u4f9d\u8d56\u578b\u57f9\u517b\u65b9\u6cd5\u7684\u65b9\u6848\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5176\u6765\u6e90\u4e8e\u5c0f\u9f20\u8089\u7624\uff0c\u56e0\u6b64\u5b58\u5728\u5f02\u79cd\u6c61\u67d3\u7684\u98ce\u9669\u3002.<\/p><p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u4e86\u66f4\u660e\u786e\u7684\u5e95\u7269\uff0c\u5305\u62ec\u7279\u5b9a\u7684\u5c42\u7c98\u8fde\u86cb\u767d\u4e9a\u578b\uff08-511\/-521\uff09\u3001\u73bb\u8fde\u86cb\u767d\u548cE-\u9499\u9ecf\u86cb\u767d\u3002\u57fa\u4e8e\u5408\u6210\u805a\u5408\u7269\u7684\u5e73\u53f0\uff0c\u4f8b\u5982PMEDSAH\u548c\u6c28\u4e19\u57fa\u7532\u57fa\u4e19\u70ef\u9170\u80fa\uff08APMAAm\uff09\u7b49\u4e24\u6027\u79bb\u5b50\u6c34\u51dd\u80f6\uff0c\u63d0\u9ad8\u4e86\u5b9e\u9a8c\u7684\u91cd\u590d\u6027\u3002\u77f3\u58a8\u70ef\u57fa\u8868\u9762\u6709\u671b\u5728\u65e0\u9700\u7ec6\u80de\u5916\u57fa\u8d28\u5305\u88ab\u7684\u60c5\u51b5\u4e0b\u7ef4\u6301\u7ec6\u80de\u7684\u591a\u80fd\u6027\u3002.<\/p><h3 class=\"wp-block-heading\">\u5b9a\u5411\u5206\u5316\u7684\u751f\u957f\u56e0\u5b50\u65b9\u6848<\/h3><p 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class=\"wp-block-paragraph\">\u7279\u5b9a\u7684\u751f\u957f\u56e0\u5b50\u7ec4\u5408\u5f15\u5bfc\u8c31\u7cfb\u7279\u5f02\u6027\u53d1\u80b2\u3002\u795e\u7ecf\u5206\u5316\u9700\u8981bFGF\u3001\u809d\u7d20\u548cN2\u8865\u5145\u5242\u300210\u65e5\u9f84\u80da\u72b6\u4f53\u81ea\u7136\u5206\u5316\u4e3a\u5fc3\u810f\u7ec6\u80de\uff0c\u800c\u6fc0\u6d3b\u7d20A\u5219\u9a71\u52a8\u5185\u80da\u5c42\u8bf1\u5bfc\u3002BMP-4\u3001TGF-\u03b21\u3001\u7ef4\u7532\u9178\u548cHGF\u901a\u8fc7\u6fc0\u6d3b\u4e0d\u540c\u7684\u4fe1\u53f7\u901a\u8def\u5f15\u5bfc\u7ec6\u80de\u8d70\u5411\u7279\u5b9a\u7684\u547d\u8fd0\u3002 .<\/p><h3 class=\"wp-block-heading\">\u7528\u4e8e\u7ec4\u7ec7\u7279\u5f02\u6027\u53d1\u80b2\u76843D\u7c7b\u5668\u5b98\u6a21\u578b<\/h3><p 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href=\"https:\/\/www.lechengmedical.com\/zh\/boost-recovery-discover-what-stem-cells-can-do-now\/\">\u7ec6\u80de\u53ef\u4ee5<\/a> \u8f6c\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u2014\u2014\u5e15\u91d1\u68ee\u75c5\u4e2d\u4e3b\u8981\u4e22\u5931\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u79fb\u690d\u7684\u7ec6\u80de\u80fd\u591f\u5b58\u6d3b\uff0c\u5e76\u901a\u8fc7\u5206\u6ccc\u591a\u5df4\u80fa\u548c\u63d0\u4f9b\u8425\u517b\u652f\u6301\u6765\u5e2e\u52a9\u6cbb\u7597\u3002.<\/p><p 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class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The way stem cells distinguish themselves from other cells is one of the most captivating processes I&#8217;ve studied in medical science. These master cells stand out as the body&#8217;s only cells that can turn into over 200 different specialized cell types. They&#8217;re quite remarkable &#8211; unlike regular cells that have limited lifespans, stem cells keep [&#8230;]<\/p>\n","protected":false},"author":2,"featured_media":156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[4],"tags":[17,110,129],"class_list":["post-155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-benefits-of-stem-cells","tag-stem-cell-differentiation","tag-stem-cells-and-cell-differentiation"],"_links":{"self":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts\/155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/comments?post=155"}],"version-history":[{"count":0,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/posts\/155\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/media\/156"}],"wp:attachment":[{"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/media?parent=155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/categories?post=155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lechengmedical.com\/zh\/wp-json\/wp\/v2\/tags?post=155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}